Myocardial Function in Fetuses with Congenital Cytomegalovirus Infection
Introduction: The objective of this study was to investigate myocardial deformation of left (LV) and right ventricle (RV) using 2-dimensional speckle-tracking echocardiography (2D-STE) in fetuses with and without congenital cytomegalovirus (CMV) infection. Methods: This was a prospective single-center study. Vertical transmission was defined by a positive CMV polymerase chain reaction (PCR) test on the amniotic fluid or on the neonate’s urine. Fetuses were divided into group 1 and group 2 if CMV-PCR was positive or negative, respectively. LV and RV global longitudinal strain (GLS) values were obtained and adjusted for gestational age by calculating Z-scores. Univariate analysis was carried out to compare cardiac indices between group 1 and group 2. Results: Fetuses from group 1 (n = 11) had a significantly lower LV myocardial shortening than those from group 2 (n = 32). GLS was −20.7 ± 5.2% and −26.3 ± 4.1%, respectively (p = 0.001). Similarly, GLS Z-score was lower (0.02 ± 0.72) in group 1 than in group 2 (−0.80 ± 0.59) (p = 0.001). Similarly, RV GLS Z-score was significantly impaired in group 1 compared to group 2 (−0.44 ± 1.03 vs. −1.04 ± 0.71, p = 0.041). Conclusion: Fetuses with congenital CMV showed subclinical biventricular myocardial dysfunction. Further studies are needed to confirm the potential role of 2D-STE in identifying fetuses with congenital CMV at risk of postnatal cardiovascular morbidities.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Myocardial Function in Fetuses with Congenital Cytomegalovirus Infection ; volume:50 ; number:6 ; year:2023 ; pages:430-437 ; extent:8
Fetal diagnosis and therapy ; 50, Heft 6 (2023), 430-437 (gesamt 8)
- Creator
-
Giorgione, Veronica
Krajden Haratz, Karina
Gull, Ilan
Brusilov, Michael
Birnbaum, Roee
Blecher, Yair
Malinger, Gustavo
Kaplan, Alon
Beer, Gil
Kapusta, Livia
- DOI
-
10.1159/000533280
- URN
-
urn:nbn:de:101:1-2023121323234155437430
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:32 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Giorgione, Veronica
- Krajden Haratz, Karina
- Gull, Ilan
- Brusilov, Michael
- Birnbaum, Roee
- Blecher, Yair
- Malinger, Gustavo
- Kaplan, Alon
- Beer, Gil
- Kapusta, Livia
Other Objects (12)
Fetal Brain Damage in Human Fetuses with Congenital Cytomegalovirus Infection: Histological Features and Viral Tropism
Immunological response in congenital cytomegalovirus infection
Cytomegalovirus Genotype and Virulence in Infants with Congenital Infection
Isolated auditory neuropathy at birth in congenital cytomegalovirus infection
An unusual case of congenital cytomegalovirus infection-related retinopathy
Congenital cytomegalovirus infection after maternal persistent immunoglobulin-M antibodies against cytomegalovirus prior to conception
Human Cytomegalovirus: detection of congenital and perinatal infection in Argentina
Congenital cytomegalovirus infection presenting as a fetal intra-abdominal cyst
Neurobehavioral outcomes of neonatal asymptomatic congenital cytomegalovirus infection at 12-months
The association between maternal cytomegalovirus urinary excretion and congenital infection rate
Human cytomegalovirus envelope glycoprotein B as pathogenicity factor for congenital infection
Rare etiology of arthrogryposis multiplex congenita at term: congenital cytomegalovirus infection
Fetal Brain Damage in Human Fetuses with Congenital Cytomegalovirus Infection: Histological Features and Viral Tropism
Immunological response in congenital cytomegalovirus infection
Cytomegalovirus Genotype and Virulence in Infants with Congenital Infection
Isolated auditory neuropathy at birth in congenital cytomegalovirus infection
An unusual case of congenital cytomegalovirus infection-related retinopathy
Congenital cytomegalovirus infection after maternal persistent immunoglobulin-M antibodies against cytomegalovirus prior to conception
Human Cytomegalovirus: detection of congenital and perinatal infection in Argentina
Congenital cytomegalovirus infection presenting as a fetal intra-abdominal cyst
Neurobehavioral outcomes of neonatal asymptomatic congenital cytomegalovirus infection at 12-months
The association between maternal cytomegalovirus urinary excretion and congenital infection rate
Human cytomegalovirus envelope glycoprotein B as pathogenicity factor for congenital infection
Rare etiology of arthrogryposis multiplex congenita at term: congenital cytomegalovirus infection
Fetal Brain Damage in Human Fetuses with Congenital Cytomegalovirus Infection: Histological Features and Viral Tropism
Immunological response in congenital cytomegalovirus infection
Cytomegalovirus Genotype and Virulence in Infants with Congenital Infection
Isolated auditory neuropathy at birth in congenital cytomegalovirus infection
An unusual case of congenital cytomegalovirus infection-related retinopathy
Congenital cytomegalovirus infection after maternal persistent immunoglobulin-M antibodies against cytomegalovirus prior to conception
Human Cytomegalovirus: detection of congenital and perinatal infection in Argentina
Congenital cytomegalovirus infection presenting as a fetal intra-abdominal cyst
Neurobehavioral outcomes of neonatal asymptomatic congenital cytomegalovirus infection at 12-months
The association between maternal cytomegalovirus urinary excretion and congenital infection rate
Human cytomegalovirus envelope glycoprotein B as pathogenicity factor for congenital infection