Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments **
Abstract: The invasion of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Investigating the remodeling of local extracellular matrix (ECM) by invading cells can thus provide fundamental insights into the dynamics of cancer progression. In this paper, we use an active untethered nanomechanical tool, realized as magnetically driven nanomotors, to locally probe a 3D tissue culture environment. We observed that nanomotors preferentially adhere to the cancer‐proximal ECM and magnitude of the adhesive force increased with cell lines of higher metastatic ability. We experimentally confirmed that sialic acid linkage specific to cancer‐secreted ECM makes it differently charged, which causes this adhesion. In an assay consisting of both cancerous and non‐cancerous epithelia, that mimics the in vivo histopathological milieu of a malignant breast tumor, we find that nanomotors preferentially decorate the region around the cancer cells.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments ** ; volume:132 ; number:52 ; year:2020 ; pages:23898-23904 ; extent:7
Angewandte Chemie ; 132, Heft 52 (2020), 23898-23904 (gesamt 7)
- Creator
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Dasgupta, Debayan
Pally, Dharma
Saini, Deepak K.
Bhat, Ramray
Ghosh, Ambarish
- DOI
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10.1002/ange.202008681
- URN
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urn:nbn:de:101:1-2022052812470760909171
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Dasgupta, Debayan
- Pally, Dharma
- Saini, Deepak K.
- Bhat, Ramray
- Ghosh, Ambarish
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Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts
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