A new tool for sepsis screening in the Emergency Department
Objectives: In this study, we developed and evaluated the diagnostic accuracy of the Sepsis Index for early sepsis screening in the Emergency Department (ED). Methods: Sepsis Index is based on the combination of monocyte distribution width (MDW) and mean monocyte volume (MMV). Sepsis Index≥1 was selected to define sepsis. We tested its diagnostic accuracy in an ED population stratified in four groups: controls, Systemic Inflammatory Response Syndrome (SIRS), infection, and sepsis, according to Sepsis-2 criteria. Results: Patients with sepsis displayed higher median Sepsis Index value than patients without sepsis. At the receiver operating characterictis (ROC) curve analysis for the prediction of sepsis, the area under the curve (AUC) of MDW and Sepsis Index were similar: 0.966 (95%CI 0.947–0.984), and 0.964 (95%CI 0.942–0.985), respectively. Sepsis Index showed increased specificity than MDW (94.7 vs. 90.6%), without any decrease in sensitivity (92.0%). Additionally, LR+ increased from 9.8 (MDW) to 17.4 (Sepsis Index), without any substantial change in LR− (respectively 0.09 vs. 0.08). Finally, PPV increased from 0.286 (MDW) to 0.420 (Sepsis Index). Conclusions: Sepsis Index improves the diagnostic accuracy of MDW alone for sepsis screening.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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A new tool for sepsis screening in the Emergency Department ; volume:59 ; number:9 ; year:2021 ; pages:1600-1605 ; extent:06
Clinical chemistry and laboratory medicine ; 59, Heft 9 (2021), 1600-1605 (gesamt 06)
- Creator
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Agnello, Luisa
Iacona, Alessandro
Lo Sasso, Bruna
Scazzone, Concetta
Pantuso, Michele
Giglio, Rosaria Vincenza
Gambino, Caterina Maria
Ciaccio, Anna Maria
Bivona, Giulia
Vidali, Matteo
Ciaccio, Marcello
- DOI
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10.1515/cclm-2021-0208
- URN
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urn:nbn:de:101:1-2022062013263144701125
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Agnello, Luisa
- Iacona, Alessandro
- Lo Sasso, Bruna
- Scazzone, Concetta
- Pantuso, Michele
- Giglio, Rosaria Vincenza
- Gambino, Caterina Maria
- Ciaccio, Anna Maria
- Bivona, Giulia
- Vidali, Matteo
- Ciaccio, Marcello
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Derivation and internal validation of the screening to enhance prehospital identification of sepsis (SEPSIS) score in adults on arrival at the emergency department
High blood pressure in the emergency department as an opportunistic screening tool for detection of hypertension
Drug-related emergency department visits: external validation of an assessment tool in a general emergency department population
Predictors of early progression to severe sepsis or shock among emergency department patients with nonsevere sepsis
Challenges and Opportunities for Emergency Department Sepsis Screening at Triage
Diagnostic accuracy of a screening electronic alert tool for severe sepsis and septic shock in the emergency department
Emergency department-based cancer screening interventions
Management of sepsis and septic shock in the emergency department
Screening tools for sepsis identification in paramedicine and other emergency contexts: a rapid systematic review
Delirium screening in the emergency department: evaluation and intervention
Difficulties of routine rapid HIV screening in emergency department
Emergency department screening and interventions for substance use disorders
Derivation and internal validation of the screening to enhance prehospital identification of sepsis (SEPSIS) score in adults on arrival at the emergency department
High blood pressure in the emergency department as an opportunistic screening tool for detection of hypertension
Drug-related emergency department visits: external validation of an assessment tool in a general emergency department population
Predictors of early progression to severe sepsis or shock among emergency department patients with nonsevere sepsis
Challenges and Opportunities for Emergency Department Sepsis Screening at Triage
Diagnostic accuracy of a screening electronic alert tool for severe sepsis and septic shock in the emergency department
Emergency department-based cancer screening interventions
Management of sepsis and septic shock in the emergency department
Screening tools for sepsis identification in paramedicine and other emergency contexts: a rapid systematic review
Delirium screening in the emergency department: evaluation and intervention
Difficulties of routine rapid HIV screening in emergency department
Emergency department screening and interventions for substance use disorders
Derivation and internal validation of the screening to enhance prehospital identification of sepsis (SEPSIS) score in adults on arrival at the emergency department
High blood pressure in the emergency department as an opportunistic screening tool for detection of hypertension
Drug-related emergency department visits: external validation of an assessment tool in a general emergency department population