Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes
Abstract: Type 2 diabetes mellitus (T2DM) is known as a risk factor for coronary in-stent restenosis (ISR) in patients with coronary artery disease (CAD). Evidence suggests that B cells play a functional role in the progression of atherosclerotic lesions. However, the B cell receptor (BCR) repertoire in patients with ISR remains unclear. This study aims to profile the BCR repertoire in patients with coronary ISR/T2DM. A total of 21 CAD patients with or without ISR/T2DM were enrolled. PBMCs were isolated and examined for BCR repertoire profiles using DNA-seq. Our results showed that the diversity of amino acid sequences in ISR DM patients was higher than that in ISR −DM patients. The frequencies of 21 V/J paired genes differed between ISR DM and −ISR DM patients, while frequencies of 5 V/J paired genes differed between ISR DM and ISR −DM. The −ISR −DM group presented the highest clonotype overlap rate, while ISR DM patients presented the lowest overlap rate. Our study presented the BCR repertoires in patients with ISR/T2DM. The data suggested different BCR signatures between patients with ISR and T2DM. Further analysis of BCR profiles would enhance understanding of ISR.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes ; volume:16 ; number:1 ; year:2021 ; pages:884-898 ; extent:15
Open life sciences ; 16, Heft 1 (2021), 884-898 (gesamt 15)
- Creator
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Weng, Ruiqiang
Liu, Sudong
Gu, Xiaodong
Zhong, Zhixiong
- DOI
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10.1515/biol-2021-0091
- URN
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urn:nbn:de:101:1-2022091914350577532944
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Weng, Ruiqiang
- Liu, Sudong
- Gu, Xiaodong
- Zhong, Zhixiong
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