The degree of pharyngeal deformation caused by pharyngeal endoscopic submucosal dissection is associated with the incidence of aspiration pneumonia

Background Endoscopic submucosal dissection (ESD) is one of the most minimally invasive treatments for superficial squamous cell cancer of the pharynx. However, aspiration pneumonia (AsP) associated with postoperative deformity of the pharynx may occur. The purpose of this study was to investigate the frequency of AsP and the degree of pharyngeal deformity after pharyngeal ESD. Methods This was a retrospective observational study of patients who underwent pharyngeal ESD at Okayama University Hospital between 2006 and 2017. The degree of pharyngeal deformation was assessed using the pharyngeal deformation grade (PDG). The primary endpoint was the frequency of AsP as a long-term adverse event. Results Among the 52 patients enrolled, nine developed aspiration pneumonia, with a three-year cumulative incidence of 9.0% (95% CI, 3.3%-22.0%). There were 16, 18, 16, and 2 patients that had PDG 0, 1, 2, and 3, respectively. Patients with a history of radiotherapy, as a treatment of head and neck cancer (44.4% vs. 11.6%; p = 0.02) and the high PDG group (PDG 2 and 3) (77.8% vs. 25.6%; p = 0.005) had a significantly higher incidence of AsP. The three-year cumulative incidence rate of AsP after ESD in the high PDG group was significantly higher than that in the low PDG group (PDG 0 and 1) (23.9% [95%CI, 9.2. -49.5%] vs. 0%; p = 0.03). Conclusions The incidence of aspiration pneumonia in the long-term course after pharyngeal ESD was revealed. The incidence of aspiration pneumonia may be associated with pharyngeal deformity, but further studies are needed.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: The degree of pharyngeal deformation caused by pharyngeal endoscopic submucosal dissection is associated with the incidence of aspiration pneumonia ; day:13 ; month:02 ; year:2023 ; Endoscopy International Open ; (13.02.2023)

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Abe, Makoto ; Kawahara, Yoshiro ; Obayashi, Yuka ; Baba, Yuki ; Hamada, Kenta ; Sakae, Hiroyuki ; Kono, Yoshiyasu ; Kanzaki, Hiromitsu ; Iwamuro, Masaya ; Kawano, Seiji ; Mkino, Takuma ; Noda, Yohei ; Marunaka, Hidenori ; Okada, Hiroyuki

Weitere Informationen

• DOI: 10.1055/a-2033-9707
• URN: urn:nbn:de:101:1-2023033011451833609072
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 11:02 MESZ