Left cardiac vagotomy rapidly reduces contralateral cardiac vagal electrical activity in anesthetized Göttingen minipigs

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Abstract: Background
The impact of acute unilateral injury on spontaneous electrical activity in both vagus nerves at the heart level is poorly understood. We investigated the immediate neuroelectrical response after right or left cardiac vagal nerve transection (VNTx) by recording spiking activity of each heart vagus nerve (VN).

Methods
Fourteen male Göttingen minipigs underwent sternotomy. Multi-electrode cuffs were implanted below the cut level to record vagal electroneurographic signals during electrocardiographic and hemodynamic monitoring, before and immediately after cardiac VNTx (left: L-cut, n = 6; right: R-cut, n = 8).

Results
Left cardiac VNTx significantly reduced multi-unit electrical activity (MUA) firing rate in the vagal stump (−30.7% vs pre-cut) and intact right VN (−21.8% vs pre-cut) at the heart level, without affecting heart rate, heart rate variability, or hemodynamics. In contrast, right cardiac VNTx did not acutely alter MUA in either VN but slightly increased (p < 0.022) the root mean square of successive RR interval differences (rMSSD), an index of parasympathetic outflow, without affecting hemodynamics.

Conclusions
Our study reveals an early left-lateralized pattern in vagal spiking activity following unilateral cardiac vagotomy. These findings enhance understanding of the neuroelectrical response to vagal injury and provide insights into preserving vagal outflow after unilateral cardiac vagotomy. Importantly, monitoring spiking activity of the cardiac right VN may predict onset of left vagal pathway injury, which is detrimental to cardiac patients and can occur as a complication of catheter ablation for atrial fibrillation

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: International journal of cardiology. - 394 (2024) , 131349, ISSN: 1874-1754

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2024

Creator: Vallone, Fabio
Dushpanova, Anar
Leali, Marco
Strauss, Ivo
Agnesi, Filippo
Zinno, Ciro
Casieri, Valentina
Carrozzo, Alessandro
Bernini, Fabio
Terlizzi, Domiziana
Carpaneto, Jacopo
Micera, Silvestro
Lionetti, Vincenzo

DOI: 10.1016/j.ijcard.2023.131349

URN: urn:nbn:de:bsz:25-freidok-2531909

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:45 AM CEST

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Associated

Vallone, Fabio
Dushpanova, Anar
Leali, Marco
Strauss, Ivo
Agnesi, Filippo
Zinno, Ciro
Casieri, Valentina
Carrozzo, Alessandro
Bernini, Fabio
Terlizzi, Domiziana
Carpaneto, Jacopo
Micera, Silvestro
Lionetti, Vincenzo
Universität

Time of origin

2024

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Left cardiac vagotomy rapidly reduces contralateral cardiac vagal electrical activity in anesthetized Göttingen minipigs

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Other Objects (12)

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Suppression of vagal cardiac modulation by blue light in healthy subjects

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B fibers are the best predictors of cardiac activity during Vagus nerve stimulation : Qing, vagal B fiber activation and cardiac effects

Decomposition of heart rate variability by adaptive filtering for estimation of cardiac vagal tone

Rapidly reversible acute neurological, renal, and cardiac impairment during malignant hypertension

Long-term CPAP treatment partially improves the link between cardiac vagal influence and delta sleep

A multi-channel stimulator with an active electrode array implant for vagal-cardiac neuromodulation studies

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Determining cardiac vagal threshold from short term heart rate complexity

Commentary: Vagal tank theory: the three Rs of cardiac vagal control functioning : resting, reactivity, and recovery

Rapidly growing cardiac myxoma diagnosed within 1 year after unremarkable prior cardiac imaging

Suppression of vagal cardiac modulation by blue light in healthy subjects

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B fibers are the best predictors of cardiac activity during Vagus nerve stimulation : Qing, vagal B fiber activation and cardiac effects

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Rapidly reversible acute neurological, renal, and cardiac impairment during malignant hypertension

Long-term CPAP treatment partially improves the link between cardiac vagal influence and delta sleep

A multi-channel stimulator with an active electrode array implant for vagal-cardiac neuromodulation studies

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Rapidly growing cardiac myxoma diagnosed within 1 year after unremarkable prior cardiac imaging

Suppression of vagal cardiac modulation by blue light in healthy subjects

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