When is an Imine Directing Group a Transient Imine Directing Group in C−H Functionalization?

Abstract: ‘Transient’ C−H functionalization has emerged in recent years to describe the use of a dynamic linkage, often an imine, to direct cyclometallation and subsequent functionalization. As the field continues to grow in popularity, we consider the features that make an imine directing group transient. A transient imine should be i) formed dynamically in situ, ii) avoid discrete introduction or cleavage steps, and iii) offer the potential for catalysis in both the directing group and metal. This concept article contrasts transient imines with pioneering early studies of imines as directing groups for the formation of metallacycles and the use of preformed imines in C−H functionalization. Leading developments in the use of catalytic additives to form transient directing groups (as aldehyde or amine) are covered including selected highlights of the most recent examples of catalytic imine directed C−H functionalization with transition metals.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: When is an Imine Directing Group a Transient Imine Directing Group in C−H Functionalization? ; day:12 ; month:03 ; year:2024 ; extent:9 ; Chemistry - a European journal ; (12.03.2024) (gesamt 9)

Contributors, Places and Time

• Creator: Higham, Joe I. ; Ma, Tsz‐Kan ; Bull, James A.

Further information

• DOI: 10.1002/chem.202400345
• URN: urn:nbn:de:101:1-2024031313144724250161
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:55 AM CEST