A Review of Inline Infrared and Nuclear Magnetic Resonance Applications in Flow Chemistry

Abstract: As a safe and efficient synthesis technique, flow chemistry has recently gained attention in the pharmaceutical, materials, and environmental protection industries. However, researchers always face challenges in handling samples and selecting sufficiently flexible analytical techniques. Generally, real-time process analysis is crucial for monitoring reactions. The combination of flow chemistry with real-time process analysis can be beneficial for studying reaction kinetics and thermodynamics, monitoring, and control of the chemical synthesis processes, reaction optimization of macro and microreactors, and qualitative and quantitative analyses of compounds. Thus far, studies investigating the combination of flow chemistry with inline monitoring have included ultraviolet–infrared spectroscopy, Raman spectroscopy, gas chromatography, mass spectrometry, liquid chromatography, nuclear magnetic resonance (NMR) spectroscopy, and other automated conventional or unconventional methods. This review sheds light on applying inline infrared and inline NMR spectroscopies in flow chemistry.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: A Review of Inline Infrared and Nuclear Magnetic Resonance Applications in Flow Chemistry ; volume:05 ; number:04 ; year:2023 ; pages:e209-e218 ; Pharmaceutical fronts ; 05, Heft 04 (2023), e209-e218

Contributors, Places and Time

• Contributor: Zhang, Yan ; Su, Wei-Ke

Further information

• DOI: 10.1055/s-0043-1776906
• URN: urn:nbn:de:101:1-2024020811002521424040
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:38 AM CEST