Chemical Synthesis of Bioactive Proteins
Abstract: Nature has developed a plethora of protein machinery to operate and maintain nearly every task of cellular life. These processes are tightly regulated via post‐expression modifications—transformations that modulate intracellular protein synthesis, folding, and activation. Methods to prepare homogeneously and precisely modified proteins are essential to probe their function and design new bioactive modalities. Synthetic chemistry has contributed remarkably to protein science by allowing the preparation of novel biomacromolecules that are often challenging or impractical to prepare via common biological means. The ability to chemically build and precisely modify proteins has enabled the production of new molecules with novel physicochemical properties and programmed activity for biomedical research, diagnostic, and therapeutic applications. This minireview summarizes recent developments in chemical protein synthesis to produce bioactive proteins, with emphasis on novel analogs with promising in vitro and in vivo activity.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Chemical Synthesis of Bioactive Proteins ; day:01 ; month:02 ; year:2023 ; extent:20
Angewandte Chemie ; (01.02.2023) (gesamt 20)
- Creator
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Harel, Omer
Jbara, Muhammad
- DOI
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10.1002/ange.202217716
- URN
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urn:nbn:de:101:1-2023020214200779610248
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Harel, Omer
- Jbara, Muhammad
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Total chemical synthesis of proteins
Synthesis of bioactive scaffolds
Development of a focused chemical library: synthesis of novel bioactive hymenialdisine derivatives
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Multicomponent synthesis : bioactive heterocycles
Synthesis of novel bioactive doxycycline derivatives
Synthesis of novel bioactive doxycycline derivatives
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Chemical Synthesis of Alpha‐Synuclein Proteins via Solid‐Phase Peptide Synthesis and Native Chemical Ligation
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Total chemical synthesis of proteins
Synthesis of bioactive scaffolds
Development of a focused chemical library: synthesis of novel bioactive hymenialdisine derivatives
Chemical Synthesis and Semisynthesis of Lipidated Proteins
Multicomponent synthesis : bioactive heterocycles
Synthesis of novel bioactive doxycycline derivatives
Synthesis of novel bioactive doxycycline derivatives
Progress in Chemical Synthesis of Peptides and Proteins
Chemical Synthesis of Alpha‐Synuclein Proteins via Solid‐Phase Peptide Synthesis and Native Chemical Ligation
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