An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map
Abstract: Cryo-electron microscopy (Cryo-EM) is a powerful technique to produce 3-dimensional density maps for large molecular complexes. Although many atomic structures have been solved from cryo-EM density maps, it is challenging to derive atomic structures when the resolution of density maps is not sufficiently high. Geometrical shape representation of secondary structural components in a medium-resolution density map enhances modeling of atomic structures.We compare two methods in producing surface representation of the β-sheet component of a density map. Given a 3-dimensional volume of β-sheet that is segmented from a density map, the performance of a polynomial fitting was compared with that of an iterative Bézier fitting. The results suggest that the iterative Bézier fitting is more suitable for β-sheets, since it provides more accurate representation of the corners that are naturally twisted in a β-sheet.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map ; volume:5 ; number:1 ; year:2017 ; pages:31-39 ; extent:9
Computational and mathematical biophysics ; 5, Heft 1 (2017), 31-39 (gesamt 9)
- Creator
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Poteat, Michael
He, Jing
- DOI
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10.1515/mlbmb-2017-0003
- URN
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urn:nbn:de:101:1-2410261645445.513859576135
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
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Associated
- Poteat, Michael
- He, Jing
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