Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

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Location: Deutsche Nationalbibliothek Frankfurt am Main

ISSN: 1750-1326

Extent: Online-Ressource

Language: Englisch

Notes: online resource.

Bibliographic citation: Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1 ; volume:3 ; number:1 ; day:12 ; month:5 ; year:2008 ; pages:1-12 ; date:12.2008
Molecular neurodegeneration ; 3, Heft 1 (12.5.2008), 1-12, 12.2008

Creator: Carter, Donald B.

Contributor: Dunn, Edwige
Pauley, Adele M.
McKinley, Denise D.
Fleck, Timothy J.
Ellerbrook, Brenda R.
Stratman, Nancy C.
Zhou, Xiangdong
Himes, Carol S.
Nye, Jeffrey S.
Tomasselli, Alfredo
Yan, Riqiang
SpringerLink (Online service)

DOI: 10.1186/1750-1326-3-6

URN: urn:nbn:de:1111-2016073063759

Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:56 AM CEST

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Associated

Carter, Donald B.
Dunn, Edwige
Pauley, Adele M.
McKinley, Denise D.
Fleck, Timothy J.
Ellerbrook, Brenda R.
Stratman, Nancy C.
Zhou, Xiangdong
Himes, Carol S.
Nye, Jeffrey S.
Tomasselli, Alfredo
Yan, Riqiang
SpringerLink (Online service)

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Hochschulschrift

Functional characterization of the N-terminal glycine of the GxGD aspartyl protease active site motif in presenilin 1

Mapping differences in C99 cleavage efficiency and specificity exhibited by presenilin 1 and presenilin 2 to structural subdomains

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

Efficient production of a mature and functional gamma secretase protease

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

A motif-independent metric for DNA sequence specificity

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Engineering of TEV protease variants with redesigned substrate specificity

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Functional characterization of the N-terminal glycine of the GxGD aspartyl protease active site motif in presenilin 1

Mapping differences in C99 cleavage efficiency and specificity exhibited by presenilin 1 and presenilin 2 to structural subdomains

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

Efficient production of a mature and functional gamma secretase protease

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

A motif-independent metric for DNA sequence specificity

Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

Engineering of TEV protease variants with redesigned substrate specificity

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Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

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Other Objects (12)

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1

Functional characterization of the N-terminal glycine of the GxGD aspartyl protease active site motif in presenilin 1

Mapping differences in C99 cleavage efficiency and specificity exhibited by presenilin 1 and presenilin 2 to structural subdomains

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

Efficient production of a mature and functional gamma secretase protease

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

A motif-independent metric for DNA sequence specificity

Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

Engineering of TEV protease variants with redesigned substrate specificity

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1

Functional characterization of the N-terminal glycine of the GxGD aspartyl protease active site motif in presenilin 1

Mapping differences in C99 cleavage efficiency and specificity exhibited by presenilin 1 and presenilin 2 to structural subdomains

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

Efficient production of a mature and functional gamma secretase protease

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

A motif-independent metric for DNA sequence specificity

Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

Engineering of TEV protease variants with redesigned substrate specificity

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1

Functional characterization of the N-terminal glycine of the GxGD aspartyl protease active site motif in presenilin 1

Mapping differences in C99 cleavage efficiency and specificity exhibited by presenilin 1 and presenilin 2 to structural subdomains

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

Efficient production of a mature and functional gamma secretase protease

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

A motif-independent metric for DNA sequence specificity

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Engineering of TEV protease variants with redesigned substrate specificity

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