Preparation and characterization of a novel composite membrane of natural silk fiber/nano-hydroxyapatite/chitosan for guided bone tissue regeneration

Abstract: Natural silk fiber (SF) was introduced into the chitosan/nano-hydroxyapatite (CS/n-HA) system to fabricate a novel guided bone tissue regeneration (GBR) membrane. The effect of different treatment methods (degummed, un-degummed, or dissolved SF) and different contents of SF on the properties of the CS/n-HA composite membrane was investigated. Results demonstrated that the degummed SF/CS/n-HA composite membrane with a weight ratio of 2:6:2 possessed the highest mechanical strength, where SF supported the composite membrane as a skeleton frame in the form of primeval state, while the un-degummed SF and dissolved SF had weaker reinforce effect due to the poor interface or poor interaction between SF and CS, and the dissolved SF/CS/n-HA composite membrane displayed the fastest degradation. However, the three SF could all improve the cell biocompatibility of the CS/n-HA composite membrane. Conclusively, the study revealed that degummed SF could in situ reinforce the CS/n-HA composite membrane with a simple and green processing method, which would provide an important guidance significant to develop a novel GBR membrane.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Preparation and characterization of a novel composite membrane of natural silk fiber/nano-hydroxyapatite/chitosan for guided bone tissue regeneration ; volume:21 ; number:1 ; year:2021 ; pages:671-680 ; extent:10 ; e-Polymers ; 21, Heft 1 (2021), 671-680 (gesamt 10)

Contributors, Places and Time

• Creator: Tang, Shuo ; Wang, Weijia

Further information

• DOI: 10.1515/epoly-2021-0068
• URN: urn:nbn:de:101:1-2412151618189.230415743040
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:29 AM CEST