Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes

Objectives: Although the vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS Cov-2) is considered safe during pregnancy, vaccine hesitancy among pregnant women is high. The results of published observational studies addressing the issue of Covid-19 vaccination’s efficacy and safety during pregnancy need to be summarized. Content: This systematic review compares the incidence of major maternal and neonatal outcomes between SARS Cov-2 vaccinated and unvaccinated pregnant women. The included studies enrolled pregnant women of any age and any trimester. Medline-Pubmed, Scopus, Cochrane Library, and grey literature were searched until the 28th of May 2022, and 2,947 studies were found. Summary: Seven observational cohort studies, enrolling 67,274 pregnant women, were selected. When comparing vaccinated and unvaccinated pregnant women, SARS Cov-2 vaccines were not associated with major maternal and neonatal adverse events. The rate of SARS Cov-2 infections among vaccinated pregnant women compared to unvaccinated is significantly reduced by 43%. Outlook: SARS Cov-2 vaccination in pregnant women is effective and safe. The results are promising, but caution is advised due to some limitations: only observational studies addressing this issue were found. Parallelly, the enrolled populations and the intervention (vaccination type and the number of doses) were not homogeneous.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes ; volume:51 ; number:7 ; year:2023 ; pages:823-839 ; extent:17 ; Journal of perinatal medicine ; 51, Heft 7 (2023), 823-839 (gesamt 17)

Beteiligte, Orts- und Zeitangaben

• Urheber: Kontovazainitis, Christos-Georgios ; Katsaras, Georgios N. ; Gialamprinou, Dimitra ; Mitsiakos, Georgios

Weitere Informationen

• DOI: 10.1515/jpm-2022-0463
• URN: urn:nbn:de:101:1-2023090714144334492329
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 11:02 MESZ