Ruthenium (II)‐Catalyzed Late‐Stage Incorporation of N ‐Aryl Triazoles and Tetrazoles with Sulfonium Salts via C−H Activation
Abstract: The late‐stage functionalization of active pharmaceutical ingredients is a key challenge in medicinal chemistry. Furthermore, N‐aryl triazoles and tetrazoles are important structural motifs with the potential to boost the activity of diverse drug molecules. Using easily accessible dibenzothiophenium salts for the ruthenium‐catalyzed C−H arylation, these scaffolds were introduced into a variety of bioactive compounds. Our methodology uses cost‐efficient ruthenium, KOAc as a mild base and gives access to a plethora of highly decorated triazole and tetrazole containing drug derivatives.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Ruthenium (II)‐Catalyzed Late‐Stage Incorporation of N ‐Aryl Triazoles and Tetrazoles with Sulfonium Salts via C−H Activation ; day:08 ; month:05 ; year:2024 ; extent:7
Angewandte Chemie / International edition. International edition ; (08.05.2024) (gesamt 7)
- Creator
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Simon, Hendrik
Zangarelli, Agnese
Bauch, Tristan
Ackermann, Lutz
- DOI
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10.1002/anie.202402060
- URN
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urn:nbn:de:101:1-2405081441326.301656392662
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:50 AM CEST
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Simon, Hendrik
- Zangarelli, Agnese
- Bauch, Tristan
- Ackermann, Lutz
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