Clinical parameters affect the structure and function of superficial pyramidal neurons in the adult human neocortex
Abstract: The interplay between neuronal structure and function underpins the dynamic nature of neocortical networks. Despite extensive studies in animal models, our understanding of structure–function interrelations in the adult human brain remains incomplete. Recent methodological advances have facilitated the functional analysis of individual neurons within the human neocortex, providing a new understanding of fundamental brain processes. However, the factors contributing to patient-specific neuronal properties have not been thoroughly explored. In this observational study, we investigated the structural and functional variability of superficial pyramidal neurons in the adult human neocortex. Using whole-cell patch-clamp recordings and post hoc analyses of dendritic spine morphology in acute neocortical slice preparations from surgical resections of seven patients, we assessed age-related effects on excitatory neurotransmission, membrane properties and dendritic spine morphologies. These results specify age as an endogenous factor that might affect the structural and functional properties of superficial pyramidal neurons
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Brain communications. - 6, 5 (2024) , fcae351, ISSN: 2632-1297
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2024
- Creator
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Lenz, Maximilian Christopher
Kruse, Pia
Eichler, Amelie
Strähle, Jakob
Hemeling, Hanna
Stöhr, Phyllis
Beck, Jürgen
Vlachos, Andreas
- DOI
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10.1093/braincomms/fcae351
- URN
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urn:nbn:de:bsz:25-freidok-2586083
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
This object is provided by:
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lenz, Maximilian Christopher
- Kruse, Pia
- Eichler, Amelie
- Strähle, Jakob
- Hemeling, Hanna
- Stöhr, Phyllis
- Beck, Jürgen
- Vlachos, Andreas
- Universität
Time of origin
- 2024
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