Enoki‐Inspired Microfibers and Extracellular Matrix Enhance Biaxially Interlocking Interfaces

Taking inspiration from diverse interlocking and adhesion structures found in nature, a biaxially interlocking interface is developed in this work. This interface is formed by interconnecting two electrostatically flocked substrates and its mechanical strength is enhanced through the incorporation of enoki‐mushroom‐shaped microfibers and deposited extracellular matrix (ECM). Tips of flocked straight fibers can be transformed into mushroom shapes through thermal treatment. The tensile strength of interlocked scaffolds with mushroom‐shaped tips drastically increases when compared to scaffolds made of straight fibers, which is not reported previously. More cells proliferate within interlocked scaffolds with mushroom‐shaped tips than scaffolds with straight fibers. Additionally, the mechanical strength (e.g., compressive, tensile, and shear) of cell‐seeded interlocked scaffolds increases proportionally to the amount of ECM deposited by dermal fibroblasts. The biaxially interlocking interface developed in this study holds promise for applications in engineering interfacial tissues, modeling tissue interfaces, investigating tissue–tissue interactions, and facilitating tissue bridging or binding.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Enoki‐Inspired Microfibers and Extracellular Matrix Enhance Biaxially Interlocking Interfaces ; day:13 ; month:06 ; year:2024 ; extent:10
Small structures ; (13.06.2024) (gesamt 10)

Urheber
Tran, Huy Quang
Shreem Polavaram, Navatha
Yan, Zishuo
Lee, Donghee
Xiao, Yizhu
Shahriar, SM Shatil
Yan, Zheng
Xie, Jingwei

DOI
10.1002/sstr.202400193
URN
urn:nbn:de:101:1-2406131424527.058442969923
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:49 MESZ

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Beteiligte

  • Tran, Huy Quang
  • Shreem Polavaram, Navatha
  • Yan, Zishuo
  • Lee, Donghee
  • Xiao, Yizhu
  • Shahriar, SM Shatil
  • Yan, Zheng
  • Xie, Jingwei

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