Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis
Abstract: Oral mucositis (OM) is the most common and refractory complication of cancer chemotherapy and radiotherapy, severely affecting patients’ life quality, lowering treatment tolerance, and discouraging patient compliance. Current OM delivery systems mostly affect the comfort of patient use and lead to poor compliance and unsatisfactory effects. Herein, salivary amylases (SAs)‐responsive buccal tablets consisting of porous manganese‐substituted Prussian blue (PMPB) nanocubes (NCs), anti‐inflammatory apremilast (Apr) and starch controller have been engineered. PMPB NCs with large surface area can serve as carriers to load Apr, and their multienzyme‐mimicking activity enables them to scavenge reactive oxygen species (ROS), which thus synergize with Apr to mitigate inflammation. More significantly, the starch controller can respond to abundant SAs in the oral cavity and realize the cascade, continuous, and complete drug release after enzymatic decomposition, which not only aids with high tissue affinity to prolong the resistance time but also improves the comfort of use. The preclinical study reveals that contributed by the above actions, such buccal tablets mitigate inflammation, promote endothelium proliferation and migration, and accelerate wound healing for repressing chemotherapy‐originated intractable OM with positive oral microenvironment and shorter recovery time, thus holding high potentials in clinical translation.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Salivary Amylase‐Responsive Buccal Tablets Wipe Out Chemotherapy‐Rooted Refractory Oral Mucositis ; day:16 ; month:01 ; year:2024 ; extent:11
Advanced science ; (16.01.2024) (gesamt 11)
- Creator
-
Zhang, Yan
Wang, Taixia
Dong, Xiulin
Zhu, Chunyan
Peng, Qiuxia
Liu, Chang
Zhang,, Yifeng
Chen,, Fubo
Zhang, Kun
- DOI
-
10.1002/advs.202308439
- URN
-
urn:nbn:de:101:1-2024011714053927981093
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:29 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhang, Yan
- Wang, Taixia
- Dong, Xiulin
- Zhu, Chunyan
- Peng, Qiuxia
- Liu, Chang
- Zhang,, Yifeng
- Chen,, Fubo
- Zhang, Kun
Other Objects (12)
Understanding Recreational Services of Urban Riverfront Space for Planning Purposes : the cas of Tianjin, China
Quasiprobability fluctuation theorem behind the spread of quantum information
Cement-augmented locked plate fixation proximal humerus fractures in elderly patient: a systematic review and meta-analysis
Review of porous asphalt pavements in cold regions: the state of practice and case study repository in design, construction, and maintenance
Causal discovery and inference: concepts and recent methodological advances
The endogenous development of pastoral society: an anthropological case study in East Ujimqin Banner in Inner Mongolia
Non-fragile finite-time guaranteed cost fuzzy control for continuous-time nonlinear systems
The long-term monitoring and evaluation of cement-based grout used to govern the water seepage of karst caves in China
Comparing the Impacts of Single- and Multi-Objective Optimization on the Parameter Estimation and Performance of a Land Surface Model
A comparative study of the elasto-plastic properties for ceramic nanocomposites filled by graphene or graphene oxide nanoplates
Attitude towards working in rural areas: a cross-sectional survey of rural-oriented tuition-waived medical students in Shaanxi, China
A Wasserstein-based measure of conditional dependence
Understanding Recreational Services of Urban Riverfront Space for Planning Purposes : the cas of Tianjin, China
Quasiprobability fluctuation theorem behind the spread of quantum information
Cement-augmented locked plate fixation proximal humerus fractures in elderly patient: a systematic review and meta-analysis
Review of porous asphalt pavements in cold regions: the state of practice and case study repository in design, construction, and maintenance
Causal discovery and inference: concepts and recent methodological advances
The endogenous development of pastoral society: an anthropological case study in East Ujimqin Banner in Inner Mongolia
Non-fragile finite-time guaranteed cost fuzzy control for continuous-time nonlinear systems
The long-term monitoring and evaluation of cement-based grout used to govern the water seepage of karst caves in China
Comparing the Impacts of Single- and Multi-Objective Optimization on the Parameter Estimation and Performance of a Land Surface Model
A comparative study of the elasto-plastic properties for ceramic nanocomposites filled by graphene or graphene oxide nanoplates
Attitude towards working in rural areas: a cross-sectional survey of rural-oriented tuition-waived medical students in Shaanxi, China
A Wasserstein-based measure of conditional dependence
Understanding Recreational Services of Urban Riverfront Space for Planning Purposes : the cas of Tianjin, China
Quasiprobability fluctuation theorem behind the spread of quantum information
Cement-augmented locked plate fixation proximal humerus fractures in elderly patient: a systematic review and meta-analysis
Review of porous asphalt pavements in cold regions: the state of practice and case study repository in design, construction, and maintenance
Causal discovery and inference: concepts and recent methodological advances
The endogenous development of pastoral society: an anthropological case study in East Ujimqin Banner in Inner Mongolia
Non-fragile finite-time guaranteed cost fuzzy control for continuous-time nonlinear systems
The long-term monitoring and evaluation of cement-based grout used to govern the water seepage of karst caves in China
Comparing the Impacts of Single- and Multi-Objective Optimization on the Parameter Estimation and Performance of a Land Surface Model
A comparative study of the elasto-plastic properties for ceramic nanocomposites filled by graphene or graphene oxide nanoplates
Attitude towards working in rural areas: a cross-sectional survey of rural-oriented tuition-waived medical students in Shaanxi, China