The Efficacy and Safety of Platelet-Rich Plasma and Adipose-Derived Stem Cells: An Update

During the past decade, many studies using platelet-rich plasma (PRP) or adipose-derived stem cells (ASCs) have been conducted in various medical fields, from cardiovascular research to applications for corneal diseases. Nonetheless, there are several limitations of practical applications of PRP and ASCs. Most reports of PRP are anecdotal and few include controls to determine the specific role of PRP. There is little consensus regarding PRP production and characterization. Some have reported the development of an antibody to bovine thrombin, which was the initiator of platelet activation. In the case of ASCs, good manufacturing practices are needed for the production of clinical-grade human stem cells, and in vitro expansion of ASCs requires approval of the Korea Food and Drug Administration, such that considerable expense and time are required. Additionally, some have reported that ASCs could have a potential risk of transformation to malignant cells. Therefore, the authors tried to investigate the latest research on the efficacy and safety of PRP and ASCs and report on the current state and regulation of these stem cell-based therapies.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: The Efficacy and Safety of Platelet-Rich Plasma and Adipose-Derived Stem Cells: An Update ; volume:39 ; number:06 ; year:2012 ; pages:585-592 ; Archives of Plastic Surgery ; 39, Heft 06 (2012), 585-592

Contributors, Places and Time

• Contributor: Choi, Jaehoon ; Minn, Kyung Won ; Chang, Hak

Further information

• DOI: 10.5999/aps.2012.39.6.585
• URN: urn:nbn:de:101:1-2022061610252424419252
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:36 AM CEST