Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress
The p63 gene product regulates epithelial morphogenesis and female germline integrity. In this study, we show that cyclin‐dependent kinase 5 and Abl enzyme substrate 1 (Cables1) interacts with the trans‐activating (TA) p63α isoform to protect it from proteasomal degradation. Using the female germline of Cables1‐null mice as an in vivo model, we demonstrate further that oocytes lacking Cables1 exhibit lower basal levels of TAp63α and reduced accumulation of phosphorylated TAp63α in response to genotoxic stress. This in turn enhances the survival of these cells after ionizing radiation exposure. Thus, Cables1 modulates p63 protein stability and function during genotoxic stress.
Cables1 interacts with TAp63 to protect it from ubiquitin‐mediated degradation after exposure to genotoxic stress. Oocytes lacking Cables1 accumulate less phosphorylated TAp63 in response to genotoxic stress, which enhances the survival of these cells.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress ; volume:11 ; number:8 ; year:2010 ; pages:633-639 ; extent:7
EMBO reports / European Molecular Biology Organization ; 11, Heft 8 (2010), 633-639 (gesamt 7)
- Creator
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Wang, Ning
Guo, Lankai
Rueda, Bo R.
Tilly, Jonathan L.
- DOI
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10.1038/embor.2010.82
- URN
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urn:nbn:de:101:1-2023041916471326819492
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:47 AM CEST
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Associated
- Wang, Ning
- Guo, Lankai
- Rueda, Bo R.
- Tilly, Jonathan L.
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