LCMV‐specific CD4 T cell dependent polyclonal B‐cell activation upon persistent viral infection is short lived and extrafollicular

Abstract: Persistent virus infections with non‐ or poorly cytopathic viruses are commonly associated with B cell dysregulations. These include the induction of hypergammaglobulinemia and the emergence of virus‐unspecific antibodies. These seemingly unspecific antibody responses interfere with the virus‐specific humoral immunity and contribute to delayed virus control. Whether these virus‐unspecific antibodies are induced in the B cell follicle or at extrafollicular sites and whether one specific CD4 T cell subset is involved in the polyclonal B cell activation is unclear. Here we studied virus‐unrelated IgG antibody responses against self or foreign antigens in the context of persistent lymphocytic choriomeningitis virus (LCMV) infection. We found that the LCMV‐unspecific antibody response is short‐lived and induced predominantly at extrafollicular sites and depends on the presence of LCMV‐specific CD4 T cells. Our data support a scenario in which activated, virus‐specific CD4 T cells provide help to non‐specific B cells at extrafollicular sites, supporting the production of virus unspecific IgG antibodies during persistent viral infection.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
LCMV‐specific CD4 T cell dependent polyclonal B‐cell activation upon persistent viral infection is short lived and extrafollicular ; volume:50 ; number:3 ; year:2020 ; pages:396-403 ; extent:8
European journal of immunology ; 50, Heft 3 (2020), 396-403 (gesamt 8)

Urheber
Greczmiel, Ute
Kräutler, Nike J.
Borsa, Mariana
Pedrioli, Alessandro
Bartsch, Ilka
Richter, Kirsten
Agnellini, Paola
Bedenikovic, Gregor
Oxenius, Annette

DOI
10.1002/eji.201948286
URN
urn:nbn:de:101:1-2022062407173757115908
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:29 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.

Beteiligte

  • Greczmiel, Ute
  • Kräutler, Nike J.
  • Borsa, Mariana
  • Pedrioli, Alessandro
  • Bartsch, Ilka
  • Richter, Kirsten
  • Agnellini, Paola
  • Bedenikovic, Gregor
  • Oxenius, Annette

Ähnliche Objekte (12)