p24 proteins are required for secretion of Wnt ligands

During development and disease, the exocytosis of signalling molecules, such as Wnt ligands, is essential to orchestrate cellular programs in multicellular organisms. However, it remains a largely unresolved question whether signalling molecules follow specialized transport routes through the exocytic pathway. Here we identify several Drosophila p24 proteins that are required for Wnt signalling. We demonstrate that one of these p24 proteins, namely Opossum, shuttles in the early secretory pathway, and that the Drosophila Wnt proteins are retained in the absence of p24 proteins. Our results indicate that Wnt secretion relies on a specialized anterograde secretion route with p24 proteins functioning as conserved cargo receptors.
Wnt proteins are signalling molecules that follow a dedicated secretory pathway. The authors here identify novel components of this pathway, providing evidence that p24 proteins act as cargo receptors in an anterograde secretory route for Wnts.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: p24 proteins are required for secretion of Wnt ligands ; volume:12 ; number:12 ; year:2011 ; pages:1265-1272 ; extent:8 ; EMBO reports / European Molecular Biology Organization ; 12, Heft 12 (2011), 1265-1272 (gesamt 8)

Contributors, Places and Time

• Creator: Büchling, Tina ; Chaudhary, Varun ; Spirohn, Kerstin ; Weiß, Matthias ; Boutros, Michael

Further information

• DOI: 10.1038/embor.2011.212
• URN: urn:nbn:de:101:1-2023032112524314089602
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:54 AM CEST