Comparing complications of biologic and synthetic mesh in breast reconstruction: a systematic review and network meta-analysis

Background:In breast reconstruction, synthetic meshes are frequently used to replace acellular dermal matrix (ADM), since ADM is expensive and often leads to complications.However, there is limited evidence that compares the types of substitutes. This study aimed to compare complications between materials via a network meta-analysis. Methods:We systematically reviewed studies reporting any type of complication from 2010 to 2021. The primary outcomes were the proportion of infection, seroma, major complications, or contracture. We classified the intervention into four categories: ADM, absorbable mesh, non-absorbable mesh, and nothing used. We then performed a network meta-analysis between these categories and estimated the odds ratio with random-effect models. Results:Of 603 searched studies through the PubMed, MEDLINE, and Embase databases, following their review by two independent reviewers, 61 studies were included for full-text reading, of which 17 studies were finally included. There was a low risk of bias in the included studies, but only an indirect comparison between absorbable and non-absorbable mesh was possible. Infection was more frequent in ADM but not in the two synthetic mesh groups, namely the absorbable or non-absorbable types, compared with the non-mesh group. The proportion of seroma in the synthetic mesh group was lower (odds ratio was 0.2 for the absorbable and 0.1 for the non-absorbable mesh group) than in the ADM group. Proportions of major complications and contractures did not significantly differ between groups. Conclusion:Compared with ADM, synthetic meshes have low infection and seroma rates. However, more studies concerning aesthetic outcomes and direct comparisons are needed.

Weitere Titel
Meshes in breast reconstruction
Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Comparing complications of biologic and synthetic mesh in breast reconstruction: a systematic review and network meta-analysis ; day:20 ; month:10 ; year:2022
Archives of Plastic Surgery ; (20.10.2022)

Beteiligte Personen und Organisationen
Choi, Young-Soo
Deok-Woo, Deok-Woo
You, Hi-Jin
Lee, Tae-Yul

DOI
10.1055/a-1964-8181
URN
urn:nbn:de:101:1-2022121512103836868139
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:30 MESZ

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Beteiligte

  • Choi, Young-Soo
  • Deok-Woo, Deok-Woo
  • You, Hi-Jin
  • Lee, Tae-Yul

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