Hypervalent Iodine‐Mediated Late‐Stage Peptide and Protein Functionalization

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Abstract: Hypervalent iodine compounds are powerful reagents for the development of novel transformations. As they exhibit low toxicity, high functional group tolerance, and stability in biocompatible media, they have been used for the functionalization of biomolecules. Herein, we report recent advances up to June 2021 in peptide and protein modification using hypervalent iodine reagents. Their use as group transfer or oxidizing reagents is discussed in this Minireview, including methods targeting polar, aromatic, or aliphatic amino acids and peptide termini.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Hypervalent Iodine‐Mediated Late‐Stage Peptide and Protein Functionalization ; day:08 ; month:12 ; year:2021 ; extent:17
Angewandte Chemie / International edition. International edition ; (08.12.2021) (gesamt 17)

Creator: Allouche, Emmanuelle M. D.
Grinhagena, Elija
Waser, Jerome

DOI: 10.1002/anie.202112287

URN: urn:nbn:de:101:1-2021120914004196617283

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:24 AM CEST

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Associated

Allouche, Emmanuelle M. D.
Grinhagena, Elija
Waser, Jerome

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