Cytokines enhance human Vγ9Vδ2 T‐cell TCR‐dependent and TCR‐independent effector functions
Abstract: Vγ9Vδ2 T cells can recognize various molecules associated with cellular stress or transformation, providing a unique avenue for the treatment of cancers or infectious diseases. Nonetheless, Vγ9Vδ2 T‐cell‐based immunotherapies frequently achieve suboptimal efficacies in vivo. Enhancing the cytotoxic effector function of Vγ9Vδ2 T cells is one potential avenue through which the immunotherapeutic potential of this subset may be improved. We compared the use of four pro‐inflammatory cytokines on the effector phenotype and functions of in vitro expanded Vγ9Vδ2 T cells, and demonstrated TCR‐independent cytotoxicity mediated through CD26, CD16, and NKG2D, which could be further enhanced by IL‐23, IL‐18, and IL‐15 stimulation throughout expansion. This work defines promising culture conditions that could improve Vγ9Vδ2 T‐cell‐based immunotherapies and furthers our understanding of how this subset might recognize and target transformed or infected cells.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Cytokines enhance human Vγ9Vδ2 T‐cell TCR‐dependent and TCR‐independent effector functions ; day:13 ; month:04 ; year:2023 ; extent:12
European journal of immunology ; (13.04.2023) (gesamt 12)
- Creator
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Field, Kirsty R.
Wragg, Kathleen M.
Lee, Wen Shi
Rigau, Marc
Uldrich, Adam P.
Kent, Stephen J.
Juno, Jennifer A.
- DOI
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10.1002/eji.202250220
- URN
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urn:nbn:de:101:1-2023041315273704420029
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:51 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Field, Kirsty R.
- Wragg, Kathleen M.
- Lee, Wen Shi
- Rigau, Marc
- Uldrich, Adam P.
- Kent, Stephen J.
- Juno, Jennifer A.
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TCR-triggered extracellular superoxide production is not required for T-cell activation
HeteroTCR: A heterogeneous graph neural network-based method for predicting peptide-TCR interaction
LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity
Invariant γδTCR natural killer-like effector T cells in the naked mole-rat
Die Variabilität des Ratten iNKT TCR : = The variability of the rat iNKT TCR
Cross-TCR antagonism revealed by optogenetically tuning the half-life of the TCR ligand binding
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A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release
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