Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
Abstract: We aimed to investigate the clinical efficacy of blood purification technology based on cytokine adsorption in the treatment of sepsis. Sixty patients with sepsis were randomly divided into control (n = 30) and experimental (n = 30) groups. Both groups were given routine treatment and continuous venovenous hemofiltration, and on this basis, the experimental group received acrylonitrile/sodium methacrylate (AN69ST) blood purification. The levels of C-reactive protein, procalcitonin, white blood cell count, albumin, platelets, total bilirubin, creatinine, lactic acid, and APACE II score, as well as secretion of inflammatory factors interleukin (IL)-6 and tumor necrosis factor (TNF-α) were compared. The hospitalization time, mechanical ventilation (MV) time, drug use time, and mortality were analyzed. After treatment, the secretion levels of IL-6 and TNF-α were decreased, and other indicators were significantly improved compared with those before treatment (P < 0.05), especially in the experimental group (P < 0.05). The hospitalization time, MV time, and drug use time in the experimental group were significantly lower than those of the control group (P < 0.05), and the mortality was lower than that in the control group (P < 0.05). In conclusion, blood purification technology based on cytokine adsorption can significantly improve various indicators of sepsis patients, reduce hospitalization time, reduce mortality, and improve the prognosis.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis ; volume:18 ; number:1 ; year:2023 ; extent:9
Open medicine ; 18, Heft 1 (2023) (gesamt 9)
- Creator
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Gao, Yuqiang
Huang, Xiaohong
Yang, Yanan
Lei, Zhenlin
Chen, Qingan
Guo, Xu
Tian, Jia
Gao, Xiaoxin
- DOI
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10.1515/med-2023-0784
- URN
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urn:nbn:de:101:1-2023091314024356414662
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Gao, Yuqiang
- Huang, Xiaohong
- Yang, Yanan
- Lei, Zhenlin
- Chen, Qingan
- Guo, Xu
- Tian, Jia
- Gao, Xiaoxin
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