γ‐Oryzanol Ameliorates Depressive Behavior in Ovariectomized Mice by Regulating Hippocampal Nitric Oxide Synthase: A Potential Therapy for Menopausal Depression
Scope: Depression is a severe mental condition, common among menopausal women. γ‐Oryzanol (ORY) has various biological properties; however, the effect of ORY on menopausal depression and its underlying mechanisms have not been investigated. Methods and results: ORY is orally administered to ovariectomized (OVX) mice for 20 weeks. ORY administration results in lower immobility time in the tail suspension and forced swim test and increases locomotor activity in the open field test. In the primary hippocampal neurons and hippocampi of OVX mice, ORY treatment increases nitric oxide (NO) production and neuronal NO synthase (nNOS) expression. Further, the phosphorylation of extracellular signal‐regulated kinase (ERK), cAMP response element‐binding protein (CREB), and tropomyosin receptor kinase B, along with the expression of brain‐derived neurotrophic factior (BDNF), is upregulated. These stimulatory effects of ORY are diminished by treatment with estrogen receptor β (ERβ) antagonist. ORY similarly interacts with ERβ in the molecular docking analysis. Moreover, intracerebroventricular injection of 7‐nitroindazole, a nNOS inhibitor, abolishes the antidepressant effects of ORY. Conclusions: The results indicate that ORY attenuates depressive behavior in OVX mice by upregulating ERβ‐mediated hippocampal nNOS expression and activating the ERK‐CREB‐BDNF signaling networks. The findings suggest that ORY is a potential therapeutic agent for attenuating menopausal depression.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
γ‐Oryzanol Ameliorates Depressive Behavior in Ovariectomized Mice by Regulating Hippocampal Nitric Oxide Synthase: A Potential Therapy for Menopausal Depression ; day:06 ; month:12 ; year:2023 ; extent:13
Molecular nutrition & food research ; (06.12.2023) (gesamt 13)
- Urheber
-
Kim, Minji
Yoon, Minseok
Cho, Suengmok
Lee, Changho
Um, Min Young
- DOI
-
10.1002/mnfr.202300253
- URN
-
urn:nbn:de:101:1-2023120714015398614536
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:38 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Kim, Minji
- Yoon, Minseok
- Cho, Suengmok
- Lee, Changho
- Um, Min Young
Ähnliche Objekte (12)
Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress
Dangguijakyak-san ameliorates memory deficits in ovariectomized mice by upregulating hippocampal estrogen synthesis
Hyperoside ameliorates depression-like behavior in ovariectomized mice
Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis
The influence of Black Cohosh on hippocampal and hypothalamic gene expression profiles in ovariectomized rats and its potential to treat menopausal decrease in smell discrimination
Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats
Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats
Effect of traditional herbal medicine, danggui-yukhwang-tang, on post-menopausal weight gain in ovariectomized high-fat diet rats
Ghrelin ameliorates colonic inflammation : role of nitric oxide and sensory nerves
Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice
Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops
Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats
Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress
Dangguijakyak-san ameliorates memory deficits in ovariectomized mice by upregulating hippocampal estrogen synthesis
Hyperoside ameliorates depression-like behavior in ovariectomized mice
Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis
The influence of Black Cohosh on hippocampal and hypothalamic gene expression profiles in ovariectomized rats and its potential to treat menopausal decrease in smell discrimination
Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats
Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats
Effect of traditional herbal medicine, danggui-yukhwang-tang, on post-menopausal weight gain in ovariectomized high-fat diet rats
Ghrelin ameliorates colonic inflammation : role of nitric oxide and sensory nerves
Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice
Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops
Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats
Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress
Dangguijakyak-san ameliorates memory deficits in ovariectomized mice by upregulating hippocampal estrogen synthesis
Hyperoside ameliorates depression-like behavior in ovariectomized mice
Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis
The influence of Black Cohosh on hippocampal and hypothalamic gene expression profiles in ovariectomized rats and its potential to treat menopausal decrease in smell discrimination
Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats
Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats
Effect of traditional herbal medicine, danggui-yukhwang-tang, on post-menopausal weight gain in ovariectomized high-fat diet rats
Ghrelin ameliorates colonic inflammation : role of nitric oxide and sensory nerves
Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice
Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops