Targeted Discovery of Tetrapeptides and Cyclic Polyketide‐Peptide Hybrids from a Fungal Antagonist of Farming Termites

Abstract: Herein, we report the targeted isolation and characterization of four linear nonribosomally synthesized tetrapeptides (pseudoxylaramide A–D) and two cyclic nonribosomal peptide synthetase‐polyketide synthase‐derived natural products (xylacremolide A and B) from the termite‐associated stowaway fungus Pseudoxylaria sp. X187. The fungal strain was prioritized for further metabolic analysis based on its taxonomical position and morphological and bioassay data. Metabolic data were dereplicated based on high‐resolution tandem mass spectrometry data and global molecular networking analysis. The structure of all six new natural products was elucidated based on a combination of 1D and 2D NMR analysis, Marfey's analysis and X‐ray crystallography.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Targeted Discovery of Tetrapeptides and Cyclic Polyketide‐Peptide Hybrids from a Fungal Antagonist of Farming Termites ; volume:21 ; number:20 ; year:2020 ; pages:2991-2996 ; extent:6 ; ChemBioChem ; 21, Heft 20 (2020), 2991-2996 (gesamt 6)

Contributors, Places and Time

• Creator: Schalk, Felix ; Um, Soohyun ; Guo, Huijuan ; Kreuzenbeck, Nina B. ; Görls, Helmar ; de Beer, Z. Wilhelm ; Beemelmanns, Christine

Further information

• DOI: 10.1002/cbic.202000331
• URN: urn:nbn:de:101:1-2022061806113768146922
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:28 AM CEST