Biomimetic Hybrid Nanocontainers with Selective Permeability

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Abstract: Chemistry plays a crucial role in creating synthetic analogues of biomacromolecular structures. Of particular scientific and technological interest are biomimetic vesicles that are inspired by natural membrane compartments and organelles but avoid their drawbacks, such as membrane instability and limited control over cargo transport across the boundaries. In this study, completely synthetic vesicles were developed from stable polymeric walls and easy‐to‐engineer membrane DNA nanopores. The hybrid nanocontainers feature selective permeability and permit the transport of organic molecules of 1.5 nm size. Larger enzymes (ca. 5 nm) can be encapsulated and retained within the vesicles yet remain catalytically active. The hybrid structures constitute a new type of enzymatic nanoreactor. The high tunability of the polymeric vesicles and DNA pores will be key in tailoring the nanocontainers for applications in drug delivery, bioimaging, biocatalysis, and cell mimicry.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Biomimetic Hybrid Nanocontainers with Selective Permeability ; volume:128 ; number:37 ; year:2016 ; pages:11272-11275 ; extent:4
Angewandte Chemie ; 128, Heft 37 (2016), 11272-11275 (gesamt 4)

Creator: Messager, Lea
Burns, Jonathan R.
Kim, Jungyeon
Cecchin, Denis
Hindley, James
Pyne, Alice L. B.
Gaitzsch, Jens
Battaglia, Giuseppe
Howorka, Stefan

DOI: 10.1002/ange.201604677

URN: urn:nbn:de:101:1-2022103005364885123398

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:33 AM CEST

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Associated

Messager, Lea
Burns, Jonathan R.
Kim, Jungyeon
Cecchin, Denis
Hindley, James
Pyne, Alice L. B.
Gaitzsch, Jens
Battaglia, Giuseppe
Howorka, Stefan

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