Atroposelective Nenitzescu Indole Synthesis
Abstract: In the past decade, compounds bearing a stereogenic C−N axis have gained significant attention in fields ranging from ligand to drug design. Yet, the atroposelective synthesis of these molecules remains a considerable challenge. In contrast to recent methods using more advanced chiral catalysts, a very simply accessed Jacobsen‐type chromium (III)−salen complex was used here as a chiral enantiopure Lewis acid catalyst for a highly atroposelective Nenitzescu indole synthesis. Mild reaction conditions afforded various 5‐hydroxybenzo[g]indoles in up to 97 % yield. Moreover, through a simple work‐up, very high enantiomeric excesses of up to 99 % could be obtained.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Atroposelective Nenitzescu Indole Synthesis ; day:08 ; month:03 ; year:2023 ; extent:7
Chemistry - a European journal ; (08.03.2023) (gesamt 7)
- Urheber
- DOI
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10.1002/chem.202300279
- URN
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urn:nbn:de:101:1-2023030914160008813963
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:03 MESZ
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Beteiligte
- Thönnißen, Vinzenz
- Atodiresei, Iuliana L.
- Patureau, Frederic W.
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