A Pd‐Catalyzed Annulation Strategy to Linearly Fused Functionalized N‐Heterocycles
Abstract: Linearly fused polycyclic piperidines represent common substructures in natural products and biologically active small molecules. We have devised a Pd‐catalyzed annulation strategy to these compounds that converts readily available 2‐tetralones and indanones into these scaffolds with the potential for control of both enantio‐ and diastereoselectivity. Importantly, these compounds can be chemoselectively functionalized, providing an efficient and robust methodology to these important nitrogen‐containing molecules.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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A Pd‐Catalyzed Annulation Strategy to Linearly Fused Functionalized N‐Heterocycles ; day:20 ; month:02 ; year:2024 ; extent:7
Chemistry - a European journal ; (20.02.2024) (gesamt 7)
- Urheber
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Hoteite, Larry
Allen, Benjamin D. W.
Elhajj, Ms. Ergaiya A.
Meijer, Anthony J. H. M.
Harrity, Joseph P. A.
- DOI
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10.1002/chem.202400116
- URN
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urn:nbn:de:101:1-2024022114591797827266
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:01 MESZ
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Beteiligte
- Hoteite, Larry
- Allen, Benjamin D. W.
- Elhajj, Ms. Ergaiya A.
- Meijer, Anthony J. H. M.
- Harrity, Joseph P. A.
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Polyfunctionalizations of N-heterocycles via chemo- and regioselective metalations
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Stereoselectively fluorinated N-heterocycles: a brief survey
Aziridines Cross-Dimerize to Larger N-Heterocycles
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Polyfunctionalizations of N-heterocycles via chemo- and regioselective metalations
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