A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

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Location: Deutsche Nationalbibliothek Frankfurt am Main

ISSN: 2041-1723

Extent: Online-Ressource

Language: Englisch

Notes: online resource.

Bibliographic citation: A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis ; volume:10 ; number:1 ; day:8 ; month:4 ; year:2019 ; pages:1-13 ; date:12.2019
Nature Communications ; 10, Heft 1 (8.4.2019), 1-13, 12.2019

Classification: Naturwissenschaften

Creator: Zou, Yilong
Palte, Michael J.
Deik, Amy A.
Li, Haoxin
Eaton, John K.
Wang, Wenyu
Tseng, Yuen-Yi
Deasy, Rebecca
Kost-Alimova, Maria
Dančík, Vlado
Leshchiner, Elizaveta S.
Viswanathan, Vasanthi S.
Signoretti, Sabina
Choueiri, Toni K.
Boehm, Jesse S.
Wagner, Bridget K.
Doench, John G.
Clish, Clary B.
Clemons, Paul A.
Schreiber, Stuart L.

Contributor: SpringerLink (Online service)

DOI: 10.1038/s41467-019-09277-9

URN: urn:nbn:de:101:1-2019042311463891930219

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:54 AM CEST

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Associated

Zou, Yilong
Palte, Michael J.
Deik, Amy A.
Li, Haoxin
Eaton, John K.
Wang, Wenyu
Tseng, Yuen-Yi
Deasy, Rebecca
Kost-Alimova, Maria
Dančík, Vlado
Leshchiner, Elizaveta S.
Viswanathan, Vasanthi S.
Signoretti, Sabina
Choueiri, Toni K.
Boehm, Jesse S.
Wagner, Bridget K.
Doench, John G.
Clish, Clary B.
Clemons, Paul A.
Schreiber, Stuart L.
SpringerLink (Online service)

Other Objects (12)

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis

Correction: Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Correction to: Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis

Correction: Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Correction to: Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis

Correction: Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Correction to: Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4

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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

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Other Objects (12)

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis

Correction: Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Correction to: Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis

Correction: Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Correction to: Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis

Correction: Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Correction to: Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4

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