A single-cell atlas of chromatin accessibility in the human genome

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Abstract: Current catalogs of regulatory sequences in the human genome are still incomplete and lack cell type resolution. To profile the activity of gene regulatory elements in diverse cell types and tissues in the human body, we applied single-cell chromatin accessibility assays to 30 adult human tissue types from multiple donors. We integrated these datasets with previous single-cell chromatin accessibility data from 15 fetal tissue types to reveal the status of open chromatin for ∼1.2 million candidate cis-regulatory elements (cCREs) in 222 distinct cell types comprised of >1.3 million nuclei. We used these chromatin accessibility maps to delineate cell-type-specificity of fetal and adult human cCREs and to systematically interpret the noncoding variants associated with complex human traits and diseases. This rich resource provides a foundation for the analysis of gene regulatory programs in human cell types across tissues, life stages, and organ systems

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: ISSN: 0092-8674

Classification: Medizin, Gesundheit

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2024

Creator: Zhang, Kai
Hocker, James D.
Miller, Michael
Hou, Xiaomeng
Chiou, Joshua
Poirion, Olivier B.
Qiu, Yunjiang
Li, Yang E.
Gaulton, Kyle J.
Wang, Allen
Preißl, Sebastian
Ren, Bing

DOI: 10.1016/j.cell.2021.10.024

URN: urn:nbn:de:bsz:25-freidok-2441286

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 25.03.2025, 1:57 PM CET

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Associated

Zhang, Kai
Hocker, James D.
Miller, Michael
Hou, Xiaomeng
Chiou, Joshua
Poirion, Olivier B.
Qiu, Yunjiang
Li, Yang E.
Gaulton, Kyle J.
Wang, Allen
Preißl, Sebastian
Ren, Bing
Universität

Time of origin

2024

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A single-cell atlas of chromatin accessibility in the human genome

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Other Objects (12)

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