Genetic Survey of Psilocybe Natural Products

Abstract: Psilocybe magic mushrooms are best known for their main natural product, psilocybin, and its dephosphorylated congener, the psychedelic metabolite psilocin. Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five species (P. azurescens, P. cubensis, P. cyanescens, P. mexicana, and P. serbica) were browsed to understand more profoundly common and species‐specific metabolic capacities. The genomic analyses revealed a much greater and yet unexplored metabolic diversity than evident from parallel chemical analyses. P. cyanescens and P. mexicana were identified as aeruginascin producers. Lumichrome and verpacamide A were also detected as Psilocybe metabolites. The observations concerning the potential secondary metabolome of this fungal genus support pharmacological and toxicological efforts to find a rational basis for yet elusive phenomena, such as paralytic effects, attributed to consumption of some magic mushrooms.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Genetic Survey of Psilocybe Natural Products ; day:09 ; month:06 ; year:2022 ; extent:1 ; ChemBioChem ; (09.06.2022) (gesamt 1)

Contributors, Places and Time

• Creator: Dörner, Sebastian ; Rogge, Kai ; Fricke, Janis ; Schäfer, Tim ; Wurlitzer, Jacob M. ; Greßler, Markus ; Pham, Duyen N. K. ; Manke, David R. ; Chadeayne, Andrew R. ; Hoffmeister, Dirk

Further information

• DOI: 10.1002/cbic.202200249
• URN: urn:nbn:de:101:1-2022061015033065668421
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:20 AM CEST