Enzyme‐Triggered Reactions for the Synthesis of Organic Molecules
Abstract: The application of enzymes for the synthesis of valuable bioactive molecules, synthetic building blocks, fine chemicals and natural products is now well‐established. Biocatalysis has been embraced by industry for the preparation of both bulk chemicals and active pharmaceutical ingredients, where high activity and selectivity can be achieved with low environmental impact. In most cases, biocatalytic transformations involve functional group interconversions, such as redox and amination reactions, but do not lead to significant complexity generation in the molecule. This review explores the less prevalent enzyme‐triggered reactions, where the enzymatic transformation triggers a subsequent spontaneous reaction inter/intramolecularly. The examples highlighted in this review showcase the synthetic power of designing smart substrates for enzyme‐triggered reactions and their application for the preparation of structurally complex three‐dimensional small molecules.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Enzyme‐Triggered Reactions for the Synthesis of Organic Molecules ; day:15 ; month:11 ; year:2023 ; extent:11
European journal of organic chemistry ; (15.11.2023) (gesamt 11)
- Creator
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Martin, Aoife
Solanki, Ishita
Haarr, Marianne Bore
O'Reilly, Elaine
- DOI
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10.1002/ejoc.202300858
- URN
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urn:nbn:de:101:1-2023111614093243465522
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Martin, Aoife
- Solanki, Ishita
- Haarr, Marianne Bore
- O'Reilly, Elaine
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