Septin functions in organ system physiology and pathology

Abstract: Human septins comprise a family of 13 genes that encode for >30 protein isoforms with ubiquitous and tissue-specific expressions. Septins are GTP-binding proteins that assemble into higher-order oligomers and filamentous polymers, which associate with cell membranes and the cytoskeleton. In the last decade, much progress has been made in understanding the biochemical properties and cell biological functions of septins. In parallel, a growing number of studies show that septins play important roles for the development and physiology of specific tissues and organs. Here, we review the expression and function of septins in the cardiovascular, immune, nervous, urinary, digestive, respiratory, endocrine, reproductive, and integumentary organ systems. Furthermore, we discuss how the tissue-specific functions of septins relate to the pathology of human diseases that arise from aberrations in septin expression.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Septin functions in organ system physiology and pathology ; volume:395 ; number:2 ; year:2014 ; pages:123-141 ; extent:19 ; Biological chemistry ; 395, Heft 2 (2014), 123-141 (gesamt 19)

Beteiligte, Orts- und Zeitangaben

• Urheber: Dolat, Lee ; Hu, Qicong ; Spiliotis, Elias T.

Weitere Informationen

• DOI: 10.1515/hsz-2013-0233
• URN: urn:nbn:de:101:1-2408051720056.349119289361
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 07.04.2025, 07:57 MESZ