Azodicarboxylate‐Mediated Peptide Cyclisation: Application to Disulfide Bond Formation in Solution and Solid Phase
Abstract: Cyclic peptides are important molecules, playing key roles in protein architecture, as chemical probes, and increasingly as crucial structural elements of clinically‐useful therapeutics. Herein we report methodology using azodicarboxylates as efficient reagents for the facile synthesis of cyclic peptides through a disulfide bridge. The utility of this approach in both solution and solid‐phase, and compatibility with common amino acid side chain functionalities is demonstrated, resulting in cyclic peptides in good yield and purity. This approach has significant potential application for synthesis of molecules of biological or therapeutic significance.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Azodicarboxylate‐Mediated Peptide Cyclisation: Application to Disulfide Bond Formation in Solution and Solid Phase ; day:08 ; month:09 ; year:2023 ; extent:8
European journal of organic chemistry ; (08.09.2023) (gesamt 8)
- Creator
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Serre, Alexandra R. E.
Nwokolo, Gabriel C.
Spencer, Hannah L. M.
Bell, Timothy J.
Barnieh, Francis M.
Hughes, Laurie
Falconer, Robert A.
Morais, Goreti Ribeiro
- DOI
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10.1002/ejoc.202300789
- URN
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urn:nbn:de:101:1-2023090815370258459778
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:58 AM CEST
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Associated
- Serre, Alexandra R. E.
- Nwokolo, Gabriel C.
- Spencer, Hannah L. M.
- Bell, Timothy J.
- Barnieh, Francis M.
- Hughes, Laurie
- Falconer, Robert A.
- Morais, Goreti Ribeiro
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