Microstructural Brain Development and Neurodevelopmental Outcome of Very Preterm Infants of Mothers with Gestational Diabetes Mellitus

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Introduction: There are data linking gestational diabetes mellitus (GDM) with adverse neurodevelopmental outcome in the offspring. We investigated the effect of GDM on microstructural brain development and neurodevelopmental outcome of very preterm infants. Materials and Methods: Preterm infants <32 gestational weeks of mothers with GDM obtained cerebral magnetic resonance imaging (MRI) including diffusion-tensor imaging at term-equivalent age. For every infant, two gestational age-, sex-, and MRI scanner type-matched controls were included. Brain injury was assessed and fractional anisotropy (FA) and apparent diffusion coefficient (ADC) measured in 14 defined cerebral regions. Neurodevelopmental outcome was quantified at the corrected age of 24 months using the Bayley Scales of Infant Development. Results: We included 47 infants of mothers with GDM and 94 controls. There were no differences in neonatal morbidity between the groups, nor in any type of brain injury. The GDM group showed significantly higher FA values in the centrum semiovale, the posterior limb of the internal capsule and the pons bilaterally, in the corpus callosum and the right occipital white matter, as well as lower ADC values in the right centrum semiovale, the right occipital white matter and the corpus callosum. Neurodevelopmental outcome did not differ between the groups. Conclusion: We found no impairment of brain development in GDM-exposed infants compared to matched controls, but differences in white matter microstructure in specific regions indicating an enhanced maturation. However, neurodevelopmental outcome was equal in both groups. Further studies are needed to better understand brain maturation in preterm infants exposed to GDM.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Microstructural Brain Development and Neurodevelopmental Outcome of Very Preterm Infants of Mothers with Gestational Diabetes Mellitus ; volume:120 ; number:6 ; year:2023 ; pages:768-775 ; extent:8
Neonatology ; 120, Heft 6 (2023), 768-775 (gesamt 8)

Urheber
Sappler, Maria
Volleritsch, Nina
Hammerl, Marlene
Pellkofer, Yasmin
Griesmaier, Elke
Gizewski, Elke Ruth
Kaser, Susanne
Kiechl-Kohlendorfer, Ursula
Neubauer, Vera

DOI
10.1159/000533335
URN
urn:nbn:de:101:1-2023121323373203890230
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:38 MESZ

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Beteiligte

  • Sappler, Maria
  • Volleritsch, Nina
  • Hammerl, Marlene
  • Pellkofer, Yasmin
  • Griesmaier, Elke
  • Gizewski, Elke Ruth
  • Kaser, Susanne
  • Kiechl-Kohlendorfer, Ursula
  • Neubauer, Vera

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