Mask and Release Strategy‐Enabled Diversity‐Oriented Synthesis for DNA‐Encoded Library

to related objects

Abstract: An ideal DNA‐encoded library (DEL) selection requires the library to consist of diverse core skeletons and cover chemical space as much as possible. However, the lack of efficient on‐DNA synthetic approaches toward core skeletons has greatly restricted the diversity of DEL. To mitigate this issue, this work disclosed a “Mask & Release” strategy to streamline the challenging on‐DNA core skeleton synthesis. N‐phenoxyacetamide is used as a masked phenol and versatile directing group to mediate diversified DNA‐compatible C‐H functionalization, introducing the 1st‐dimensional diversity at a defined site, and simultaneously releasing the phenol functionality, which can facilitate the introduction of the 2nd diversity. This work not only provides a set of efficient syntheses toward DNA‐conjugated drug‐like core skeletons such as ortho‐alkenyl/sulfiliminyl/cyclopropyl phenol, benzofuran, dihydrobenzofuran but also provides a paradigm for on‐DNA core skeleton synthetic method development.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Mask and Release Strategy‐Enabled Diversity‐Oriented Synthesis for DNA‐Encoded Library ; day:03 ; month:12 ; year:2023 ; extent:9
Advanced science ; (03.12.2023) (gesamt 9)

Creator: Zhang, Silin
Zhang, Haiman
Liu, Xiawen
Qi, Ping
Tan, Tingting
Wang, Shengdong
Gao, Hui
Xu, Hongtao
Zhou, Zhi
Yi, Wei

DOI: 10.1002/advs.202307049

URN: urn:nbn:de:101:1-2023120414274509051859

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:23 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Zhang, Silin
Zhang, Haiman
Liu, Xiawen
Qi, Ping
Tan, Tingting
Wang, Shengdong
Gao, Hui
Xu, Hongtao
Zhou, Zhi
Yi, Wei

Other Objects (12)

RESEARCH ON REMOTE SENSING GEOLOGICAL INFORMATION EXTRACTION BASED ON OBJECT ORIENTED CLASSIFICATION

3D‐Printed Nanostructured Copper Substrate Boosts the Sodiated Capability and Stability of Antimony Anode for Sodium‐Ion Batteries

Developing a weighted reward criterion for the Markov-based decision of road maintenance

Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature

Quantitative determination of pore and throat parameters in tight oil reservoir using constant rate mercury intrusion technique

KMT2C mutation in a Chinese man with primary multidrug-resistant metastatic adenocarcinoma of rete testis: a case report

Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes

Phase diagram and density of SiO2–H2O fluid across critical conditions

$Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children$

Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children

Fichte Sprachlehre als Grundlage der Bewusstseinstheorie

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

RESEARCH ON REMOTE SENSING GEOLOGICAL INFORMATION EXTRACTION BASED ON OBJECT ORIENTED CLASSIFICATION

3D‐Printed Nanostructured Copper Substrate Boosts the Sodiated Capability and Stability of Antimony Anode for Sodium‐Ion Batteries

Developing a weighted reward criterion for the Markov-based decision of road maintenance

Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature

Quantitative determination of pore and throat parameters in tight oil reservoir using constant rate mercury intrusion technique

KMT2C mutation in a Chinese man with primary multidrug-resistant metastatic adenocarcinoma of rete testis: a case report

Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes

Phase diagram and density of SiO2–H2O fluid across critical conditions

$Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children$

Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children

Fichte Sprachlehre als Grundlage der Bewusstseinstheorie

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

RESEARCH ON REMOTE SENSING GEOLOGICAL INFORMATION EXTRACTION BASED ON OBJECT ORIENTED CLASSIFICATION

3D‐Printed Nanostructured Copper Substrate Boosts the Sodiated Capability and Stability of Antimony Anode for Sodium‐Ion Batteries

Developing a weighted reward criterion for the Markov-based decision of road maintenance

Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature

Quantitative determination of pore and throat parameters in tight oil reservoir using constant rate mercury intrusion technique

KMT2C mutation in a Chinese man with primary multidrug-resistant metastatic adenocarcinoma of rete testis: a case report

Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes

Phase diagram and density of SiO2–H2O fluid across critical conditions

$Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children$

Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children

Fichte Sprachlehre als Grundlage der Bewusstseinstheorie

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Mask and Release Strategy‐Enabled Diversity‐Oriented Synthesis for DNA‐Encoded Library

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

RESEARCH ON REMOTE SENSING GEOLOGICAL INFORMATION EXTRACTION BASED ON OBJECT ORIENTED CLASSIFICATION

3D‐Printed Nanostructured Copper Substrate Boosts the Sodiated Capability and Stability of Antimony Anode for Sodium‐Ion Batteries

Developing a weighted reward criterion for the Markov-based decision of road maintenance

Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature

Quantitative determination of pore and throat parameters in tight oil reservoir using constant rate mercury intrusion technique

KMT2C mutation in a Chinese man with primary multidrug-resistant metastatic adenocarcinoma of rete testis: a case report

Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes

Phase diagram and density of SiO2–H2O fluid across critical conditions

Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children

Fichte Sprachlehre als Grundlage der Bewusstseinstheorie

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

RESEARCH ON REMOTE SENSING GEOLOGICAL INFORMATION EXTRACTION BASED ON OBJECT ORIENTED CLASSIFICATION

3D‐Printed Nanostructured Copper Substrate Boosts the Sodiated Capability and Stability of Antimony Anode for Sodium‐Ion Batteries

Developing a weighted reward criterion for the Markov-based decision of road maintenance

Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature

Quantitative determination of pore and throat parameters in tight oil reservoir using constant rate mercury intrusion technique

KMT2C mutation in a Chinese man with primary multidrug-resistant metastatic adenocarcinoma of rete testis: a case report

Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes

Phase diagram and density of SiO2–H2O fluid across critical conditions

Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children

Fichte Sprachlehre als Grundlage der Bewusstseinstheorie

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

RESEARCH ON REMOTE SENSING GEOLOGICAL INFORMATION EXTRACTION BASED ON OBJECT ORIENTED CLASSIFICATION

3D‐Printed Nanostructured Copper Substrate Boosts the Sodiated Capability and Stability of Antimony Anode for Sodium‐Ion Batteries

Developing a weighted reward criterion for the Markov-based decision of road maintenance

Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature

Quantitative determination of pore and throat parameters in tight oil reservoir using constant rate mercury intrusion technique

KMT2C mutation in a Chinese man with primary multidrug-resistant metastatic adenocarcinoma of rete testis: a case report

Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes

Phase diagram and density of SiO2–H2O fluid across critical conditions

Surveillance ultrasonography for conservative treatment of femoral shaft fractures in young children

Fichte Sprachlehre als Grundlage der Bewusstseinstheorie

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

ClinoformNet-1.0: stratigraphic forward modeling and deep learning for seismic clinoform delineation

Related objects

Reset password