Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration
Abstract: Tissue regeneration involves dynamic dialogue between and among different cells and their surrounding matrices. Bone regeneration is specifically governed by reciprocity between osteoblasts and osteoclasts within the bone microenvironment. Osteoclast‐directed resorption and osteoblast‐directed formation of bone are essential to bone remodeling, and the crosstalk between these cells is vital to curating a sequence of events that culminate in the creation of bone tissue. Among bone biomaterial strategies, many have investigated the use of different material cues to direct the development and activity of osteoblasts. However, less attention has been given to exploring features that similarly target osteoclast formation and activity, with even fewer strategies demonstrating or integrating biomaterial‐directed modulation of osteoblast‐osteoclast coupling. This review aims to describe various biomaterial cues demonstrated to influence osteoclastogenesis and osteoclast function, emphasizing those that enhance a material construct's ability to achieve bone healing and regeneration. Additionally discussed are approaches that influence the communication between osteoclasts and osteoblasts, particularly in a manner that takes advantage of their coupling. Deepening the understanding of how biomaterial cues may dictate osteoclast differentiation, function, and influence on the microenvironment may enable the realization of bone‐replacement interventions with enhanced integrative and regenerative capacities.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration ; day:15 ; month:11 ; year:2024 ; extent:37
Advanced therapeutics ; (15.11.2024) (gesamt 37)
- Urheber
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Shariati, Kaavian
Bedar, Meiwand
Huang, Kelly X.
Moghadam, Shahrzad
Mirzaie, Sarah
LaGuardia, Jonnby S.
Chen, Wei
Kang, Youngnam
Ren, Xiaoyan
Lee, Justine C.
- DOI
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10.1002/adtp.202400296
- URN
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urn:nbn:de:101:1-2411151357134.780221361035
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:32 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Shariati, Kaavian
- Bedar, Meiwand
- Huang, Kelly X.
- Moghadam, Shahrzad
- Mirzaie, Sarah
- LaGuardia, Jonnby S.
- Chen, Wei
- Kang, Youngnam
- Ren, Xiaoyan
- Lee, Justine C.
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