NPM1A in plasma is a potential prognostic biomarker in acute myeloid leukemia
Objective: The aim of the study was to investigate whether nucleophosmin type A mutation (NPM1A) in plasma was associated with the prognosis of patients with acute myeloid leukemia (AML). Methods: Plasma NPM1A levels were investigated in 80 AML patients, 22 patients with benign hematopathy and 12 healthy donors by qRT-PCR. Additionally, the relationship between NPM1A levels and clinic characteristics were evaluated by Chi-square test. Kaplan-Meier method was used to analyze overall survival (OS) and relapse-free survival (RFS), and univariate and multivariate analyses were performed with Cox proportional hazard model. Results: Plasma levels of NPM1A in AML patients were significantly higher than those in benign hematopathy patients and healthy controls, respectively (both P<0.001). Additionally, high NPM1A level was significantly associated with higher WBC and platelet count (both, P<0.05). Moreover, survival analysis revealed that patients with high NPM1A levels had worse OS (P<0.001) and RFS (P<0.001). Multivariate analysis identified NPM1A as an independent prognostic predictor for AML (OS: HR=8.214, 95% CI: 2.974-22.688, P<0.001; RFS: HR=4.640, 95%CI: 1.825-11.795, P=0.001). Conclusions: Results reveal that NPM1A in plasma could serve as an ideal tool for predicting the prognosis of patients with AML.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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NPM1A in plasma is a potential prognostic biomarker in acute myeloid leukemia ; volume:13 ; number:1 ; year:2018 ; pages:236-241 ; extent:6
Open life sciences ; 13, Heft 1 (2018), 236-241 (gesamt 6)
- Urheber
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Sun, Chengming
Gao, Yujie
Yang, Liping
Shao, Huiyuan
li, Jie
Gao, Xuejun
Ma, Li
Lin, Mingming
Sui, Jingrui
- DOI
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10.1515/biol-2018-0028
- URN
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urn:nbn:de:101:1-2409201645312.432852655079
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:26 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Sun, Chengming
- Gao, Yujie
- Yang, Liping
- Shao, Huiyuan
- li, Jie
- Gao, Xuejun
- Ma, Li
- Lin, Mingming
- Sui, Jingrui
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