Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation
Abstract: Upon fertilization, the highly specialised sperm and oocyte genomes are remodelled to confer totipotency. The mechanisms of the dramatic reprogramming events that occur have remained unknown, and presumed roles of histone modifying enzymes are just starting to be elucidated. Here, we explore the function of the oocyte-inherited pool of a histone H3K4 and K9 demethylase, LSD1/KDM1A during early mouse development. KDM1A deficiency results in developmental arrest by the two-cell stage, accompanied by dramatic and stepwise alterations in H3K9 and H3K4 methylation patterns. At the transcriptional level, the switch of the maternal-to- zygotic transition fails to be induced properly and LINE-1 retrotransposons are not properly silenced. We propose that KDM1A plays critical roles in establishing the correct epigenetic landscape of the zygote upon fertilization, in preserving genome integrity and in initiating new patterns of genome expression that drive early mouse development
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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eLife. - 5 (2016) , e08851, ISSN: 2050-084X
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2019
- Urheber
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Ancelin, Katia
Syx, Laurène
Borensztein, Maud
Ranisavljevic, Noémie
Vassilev, Ivaylo
Briseño-Roa, Luis
Liu, Tao
Metzger, Eric
Servant, Nicolas
Barillot, Emmanuel
Chen, Chong-Jian
Schüle, Roland
Heard, Edith
- Beteiligte Personen und Organisationen
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Abteilung Onkologische Forschung in der Urologie
- DOI
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10.7554/elife.08851
- URN
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urn:nbn:de:bsz:25-freidok-1335598
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:24 MESZ
Datenpartner
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Beteiligte
- Ancelin, Katia
- Syx, Laurène
- Borensztein, Maud
- Ranisavljevic, Noémie
- Vassilev, Ivaylo
- Briseño-Roa, Luis
- Liu, Tao
- Metzger, Eric
- Servant, Nicolas
- Barillot, Emmanuel
- Chen, Chong-Jian
- Schüle, Roland
- Heard, Edith
- Abteilung Onkologische Forschung in der Urologie
- Universität
Entstanden
- 2019
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