ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serum γ ‐Glutamylcysteine Level
Abstract: Rheumatoid arthritis (RA) is an essential cause of labor loss and disability for people worldwide. Acanthopanax senticosus polysaccharide (ASPS) is one of the most important active components from A. senticosus, which exhibits various pharmacological activities such as antioxidation and immunomodulation. However, no studies have reported the application of ASPS in treating RA. This study aims to investigate the therapeutic effect of ASPS on RA and reveal its underlying mechanism. The potential therapeutic effect of ASPS against RA is initially verified in this study using the collagen‐induced arthritis model. Moreover, the protective benefits of ASPS are transmitted through the fecal microbiota and blocked by simultaneous antibiotic cocktail treatment, indicating that gut microbiota may be correlated with ASPS. The 16S rRNA sequencing using feces samples and untargeted UPLC‐MS metabolomics using serum samples further reveal that ASPS reprograms the arthritic progression triggered dysbiosis, enhances the expression of γ‐glutamylcysteine (GGC) synthetase, and enriches the serum concentration of GGC. Furthermore, metabolites GGC is found to be able to effectively interrupt NLRP3 inflammasome activation via inhibiting ASC nucleation and therefore attenuate inflammatory arthritis. Taken together, this work highlights ASPS's therapeutic potential against RA, which mainly exhibits its effects via modulating gut microbiota and regulating GGC production.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serum γ ‐Glutamylcysteine Level ; day:23 ; month:11 ; year:2022 ; extent:12
Advanced science ; (23.11.2022) (gesamt 12)
- Creator
-
Liu, Ang
Zhang, Min
Wu, Yanglin
Zhang, Chenhui
Zhang, Qin
Su, Xinlin
Zhu, Xu
Shi, Weidong
Liu, Jiangyun
Zhang, Yang
Huang, Cheng
Yan, Zhaowei
Lin, Jun
- DOI
-
10.1002/advs.202205645
- URN
-
urn:nbn:de:101:1-2022112414265461115471
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:23 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Liu, Ang
- Zhang, Min
- Wu, Yanglin
- Zhang, Chenhui
- Zhang, Qin
- Su, Xinlin
- Zhu, Xu
- Shi, Weidong
- Liu, Jiangyun
- Zhang, Yang
- Huang, Cheng
- Yan, Zhaowei
- Lin, Jun
Other Objects (12)
ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serumy‐Glutamylcysteine Leve
Phase separation in thin polymer films : from self stratification to polymer blend lithography
Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density in Zucker Diabetic Fatty Rats: A Short-Term Comparative Study
Robot indoor navigation point cloud map generation algorithm based on visual sensing
Ice floe segmentation and floe size distribution in airborne and high-resolution optical satellite images: towards an automated labelling deep learning approach
Buckling tests on wire arc additively manufactured SHS Columns
Strategic Conflict Management using Recurrent Multi-agent Reinforcement Learning for Urban Air Mobility Operations Considering Uncertainties
Plasma MicroRNA-29c Levels Are Associated with Carotid Intima-Media Thickness and is a Potential Biomarker for the Early Detection of Atherosclerosis
Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation
Phase Separation in Thin Polymer Films: From Self Stratification to Polymer Blend Lithography
Detection Method of Manipulator Grasp Pose Based on RGB-D Image
Anomalous ellipticity dependence in nonsequential double ionization of ArXe
ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serumy‐Glutamylcysteine Leve
Phase separation in thin polymer films : from self stratification to polymer blend lithography
Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density in Zucker Diabetic Fatty Rats: A Short-Term Comparative Study
Robot indoor navigation point cloud map generation algorithm based on visual sensing
Ice floe segmentation and floe size distribution in airborne and high-resolution optical satellite images: towards an automated labelling deep learning approach
Buckling tests on wire arc additively manufactured SHS Columns
Strategic Conflict Management using Recurrent Multi-agent Reinforcement Learning for Urban Air Mobility Operations Considering Uncertainties
Plasma MicroRNA-29c Levels Are Associated with Carotid Intima-Media Thickness and is a Potential Biomarker for the Early Detection of Atherosclerosis
Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation
Phase Separation in Thin Polymer Films: From Self Stratification to Polymer Blend Lithography
Detection Method of Manipulator Grasp Pose Based on RGB-D Image
Anomalous ellipticity dependence in nonsequential double ionization of ArXe
ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serumy‐Glutamylcysteine Leve
Phase separation in thin polymer films : from self stratification to polymer blend lithography
Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density in Zucker Diabetic Fatty Rats: A Short-Term Comparative Study
Robot indoor navigation point cloud map generation algorithm based on visual sensing
Ice floe segmentation and floe size distribution in airborne and high-resolution optical satellite images: towards an automated labelling deep learning approach
Buckling tests on wire arc additively manufactured SHS Columns
Strategic Conflict Management using Recurrent Multi-agent Reinforcement Learning for Urban Air Mobility Operations Considering Uncertainties
Plasma MicroRNA-29c Levels Are Associated with Carotid Intima-Media Thickness and is a Potential Biomarker for the Early Detection of Atherosclerosis
Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation
Phase Separation in Thin Polymer Films: From Self Stratification to Polymer Blend Lithography
Detection Method of Manipulator Grasp Pose Based on RGB-D Image