NELL1-Positive HIV-Associated Lupus-Like Membranous Nephropathy with Spontaneous Remission

Introduction: Kidney biopsy findings in patients with human immunodeficiency virus (HIV) are diverse, and optimal therapy for the various immune complex diseases in the setting of HIV is unknown. Case Presentation: A man with well-controlled HIV developed nephrotic range proteinuria, and kidney biopsy revealed lupus-like glomerulonephritis with a predominantly membranous pattern of injury. He opted for conservative therapy and experienced spontaneous and sustained remission. Subsequent testing revealed neural epidermal growth factor-like 1 (NELL1)-positive glomerular immune deposits. NELL1-positive glomerular immune deposits were identified in a total of 2 of 5 tested HIV-associated membranous nephropathy (MN), which were morphologically dissimilar and one of which weakly co-expressed phospholipase A2 receptor (PLA2R). Discussion: This case suggests potentially different outcomes in patients with immune complex diseases in the setting of HIV based on disease etiology and histopathology. HIV-associated MN is occasionally NELL1-positive.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: NELL1-Positive HIV-Associated Lupus-Like Membranous Nephropathy with Spontaneous Remission ; volume:2 ; number:4 ; year:2022 ; pages:184-188 ; extent:5 ; Glomerular Diseases ; 2, Heft 4 (2022), 184-188 (gesamt 5)

Contributors, Places and Time

• Creator: Dinesh, Kumar P. ; Charu, Vivek ; Troxell, Megan L. ; Andeen, Nicole K.

Further information

• DOI: 10.1159/000525541
• URN: urn:nbn:de:101:1-2022112323222177086105
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:27 AM CEST