Autoimmune bullous disorders
Abstract: Bullous skin diseases represent a group of organ-specific autoimmune disorders characterised by binding of circulating autoantibodies to adhesion molecules of the epidermis and the dermo-epidermal basement membrane zone. Binding of these autoantibodies to their antigenic targets results in loss of adhesion between epidermal keratinocytes and at the level of the basement membrane zone. Chronic blisters and secondary painful erosions are the clinical hallmark of autoimmune bullous disorders. Histopathology reveals the location of blister formation and helps to classify the subtype of the bullous skin disorder. Immunofluorescence is crucial for diagnosing autoimmune bullous skin disorders. Tissue-bound autoantibodies are detected by direct immunofluorescence of perilesional skin. Circulating autoantibodies can be visualised by indirect immunofluorescence using tissue substrates such as monkey oesophagus and sodium chloride-split human skin. Most of the autoantigens are available as recombinant proteins, which allows for autoantibody screening by ELISA or immunoblot analysis to confirm the primary diagnosis and, importantly, for immunoserological follow-up of patients.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Autoimmune bullous disorders ; volume:44 ; number:2 ; year:2006 ; pages:144-149
Clinical chemistry and laboratory medicine ; 44, Heft 2 (2006), 144-149
- Urheber
- DOI
-
10.1515/CCLM.2006.027
- URN
-
urn:nbn:de:101:1-2022052607475676446417
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:32 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Eming, Rüdiger
- Hertl, Michael
Ähnliche Objekte (12)
Diagnostics of autoimmune bullous diseases in German dermatology departments
Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid
Epidemiological Insights into Autoimmune Bullous Diseases in China: A Comprehensive Analysis
Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers
Correction to: Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers
Autoimmune Neuromuscular Disorders in Childhood
Bullous drug reactions
Bullous prurigo pigmentosa
Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm
Vitamin D and skeletal health in autoimmune bullous skin diseases: a case control study
Evaluierung der Krankheitsaktivität von Pemphigus-Patienten mittels des autoimmune bullous skin disorder intensity scores
Do autoimmune bullous diseases, age and gender influence the B cell receptor repertoire of humans?
Diagnostics of autoimmune bullous diseases in German dermatology departments
Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid
Epidemiological Insights into Autoimmune Bullous Diseases in China: A Comprehensive Analysis
Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers
Correction to: Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers
Autoimmune Neuromuscular Disorders in Childhood
Bullous drug reactions
Bullous prurigo pigmentosa
Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm
Vitamin D and skeletal health in autoimmune bullous skin diseases: a case control study
Evaluierung der Krankheitsaktivität von Pemphigus-Patienten mittels des autoimmune bullous skin disorder intensity scores
Do autoimmune bullous diseases, age and gender influence the B cell receptor repertoire of humans?
Diagnostics of autoimmune bullous diseases in German dermatology departments
Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid
Epidemiological Insights into Autoimmune Bullous Diseases in China: A Comprehensive Analysis
Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers
Correction to: Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers
Autoimmune Neuromuscular Disorders in Childhood
Bullous drug reactions
Bullous prurigo pigmentosa
Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm
Vitamin D and skeletal health in autoimmune bullous skin diseases: a case control study
Evaluierung der Krankheitsaktivität von Pemphigus-Patienten mittels des autoimmune bullous skin disorder intensity scores