HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function
Abstract: Failures to produce neutralizing antibodies upon HIV‐1 infection result in part from B‐cell dysfunction due to unspecific B‐cell activation. How HIV‐1 affects antigen‐specific B‐cell functions remains elusive. Using an adoptive transfer mouse model and ex vivo HIV infection of human tonsil tissue, we found that expression of the HIV‐1 pathogenesis factor NEF in CD4 T cells undermines their helper function and impairs cognate B‐cell functions including mounting of efficient specific IgG responses. NEF interfered with T cell help via a specific protein interaction motif that prevents polarized cytokine secretion at the T‐cell–B‐cell immune synapse. This interference reduced B‐cell activation and proliferation and thus disrupted germinal center formation and affinity maturation. These results identify NEF as a key component for HIV‐mediated dysfunction of antigen‐specific B cells. Therapeutic targeting of the identified molecular surface in NEF will facilitate host control of HIV infection.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function ; volume:39 ; number:24 ; year:2020 ; extent:18
The EMBO journal / European Molecular Biology Organization ; 39, Heft 24 (2020) (gesamt 18)
- DOI
-
10.15252/embj.2020105594
- URN
-
urn:nbn:de:101:1-2022062807494108054460
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:26 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Ähnliche Objekte (12)
NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigen-specific CD4+T cell polarization
Decreased inflammatory cytokine production of antigen-specific CD4+ T cells in NMDA receptor encephalitis
Cell‐Sized Lipid Vesicles as Artificial Antigen‐Presenting Cells for Antigen‐Specific T Cell Activation
Phenotype‐Based Isolation of Antigen‐Specific CD4 + T Cells in Autoimmunity: A Study of Celiac Disease
Dysfunctional dendritic cells limit antigen-specific T cell response in glioma
Isolation and characterization of antigen-specific T cell receptors
Establishment of a cell culture system for in vitro priming of human naive antigen-specific CD4+ and CD8+ T cells
Changes in CCR5+ cells and antigen-specific CD4+ T-cells during monotherapy with a CCR5 antagonist SCH532706 compared with combination therapy
Identification and characterization of antigen-specific CD4+ T cells targeting renally expressed antigens in human lupus nephritis with two independent methods
Effects of lenalidomide and pomalidomide on antigen-specific T cells
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses
MHC-based detection of antigen-specific CD8+ T cell responses
NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigen-specific CD4+T cell polarization
Decreased inflammatory cytokine production of antigen-specific CD4+ T cells in NMDA receptor encephalitis
Cell‐Sized Lipid Vesicles as Artificial Antigen‐Presenting Cells for Antigen‐Specific T Cell Activation
Phenotype‐Based Isolation of Antigen‐Specific CD4 + T Cells in Autoimmunity: A Study of Celiac Disease
Dysfunctional dendritic cells limit antigen-specific T cell response in glioma
Isolation and characterization of antigen-specific T cell receptors
Establishment of a cell culture system for in vitro priming of human naive antigen-specific CD4+ and CD8+ T cells
Changes in CCR5+ cells and antigen-specific CD4+ T-cells during monotherapy with a CCR5 antagonist SCH532706 compared with combination therapy
Identification and characterization of antigen-specific CD4+ T cells targeting renally expressed antigens in human lupus nephritis with two independent methods
Effects of lenalidomide and pomalidomide on antigen-specific T cells
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses
MHC-based detection of antigen-specific CD8+ T cell responses
NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigen-specific CD4+T cell polarization
Decreased inflammatory cytokine production of antigen-specific CD4+ T cells in NMDA receptor encephalitis
Cell‐Sized Lipid Vesicles as Artificial Antigen‐Presenting Cells for Antigen‐Specific T Cell Activation
Phenotype‐Based Isolation of Antigen‐Specific CD4 + T Cells in Autoimmunity: A Study of Celiac Disease
Dysfunctional dendritic cells limit antigen-specific T cell response in glioma
Isolation and characterization of antigen-specific T cell receptors
Establishment of a cell culture system for in vitro priming of human naive antigen-specific CD4+ and CD8+ T cells
Changes in CCR5+ cells and antigen-specific CD4+ T-cells during monotherapy with a CCR5 antagonist SCH532706 compared with combination therapy
Identification and characterization of antigen-specific CD4+ T cells targeting renally expressed antigens in human lupus nephritis with two independent methods
Effects of lenalidomide and pomalidomide on antigen-specific T cells
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses