Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone
Abstract: For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone ; volume:20 ; number:3 ; year:2014 ; pages:155-159 ; extent:5
Heterocyclic communications ; 20, Heft 3 (2014), 155-159 (gesamt 5)
- Creator
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Ren, Hui-xue
Sun, You-min
Wu, Dao-ji
Ma, Yong-shan
Ying, Han-jie
Ma, Yan
- DOI
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10.1515/hc-2014-0048
- URN
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urn:nbn:de:101:1-2501130602491.532174082805
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
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Associated
- Ren, Hui-xue
- Sun, You-min
- Wu, Dao-ji
- Ma, Yong-shan
- Ying, Han-jie
- Ma, Yan
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