Bioresorbable Insertion Aids for Brain Implantable Flexible Probes: A Comparative Study on Silk Fibroin, Alginate, and Disaccharides
Miniaturized, flexible, and biocompatible neural probes have the potential to circumvent the brain's foreign body response, but the problem of surgical implantation remains. Herein, a probe intended for implantation in the rat hippocampus is coated in four bioresorbable stiffeners to determine which is most effective in aiding insertion. The stiffeners (sucrose, maltose, silk fibroin, and alginate) are evaluated through mechanical, chemical, and dissolution tests. After coating with silk fibroin, the buckling force of the neural probe increases from 0.31 to 75.99 mN. This goes in accordance with subsequent successful insertion tests. Fourier transform infrared spectroscopy results demonstrate the increase in β‐sheet content of silk fibroin samples after treatment (e.g., water annealing) and show relevant changes due to dehydration of the alginate hydrogel. Both qualitative and quantitative dissolution studies in artificial cerebrospinal fluid illustrate that alginate and silk fibroin outlasts the disaccharide stiffeners. In this work, a variety of multidisciplinary analyses are carried out to find the best bioresorbable stiffener for deep brain implantable devices with the highest buckling force, longest dissolution time, and the most tunable structure. For the first time, an alginate hydrogel is used as a stiffener to aid insertion, expanding its usefulness beyond neural tissue engineering.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Bioresorbable Insertion Aids for Brain Implantable Flexible Probes: A Comparative Study on Silk Fibroin, Alginate, and Disaccharides ; day:01 ; month:06 ; year:2023 ; extent:13
Advanced nanoBiomed research ; (01.06.2023) (gesamt 13)
- Creator
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Cerezo-Sanchez, Maria
McGlynn, Eve
Bartoletti, Stefania
Yalagala, Bhavani Prasad
Casadei Garofani, Beatrice
Capodiferro, Arianna
Russell, Ewan
Palazzolo, Gemma
Walton, Finlay
Curia, Giulia
Heidari, Hadi
- DOI
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10.1002/anbr.202200117
- URN
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urn:nbn:de:101:1-2023060215094686561802
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:00 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cerezo-Sanchez, Maria
- McGlynn, Eve
- Bartoletti, Stefania
- Yalagala, Bhavani Prasad
- Casadei Garofani, Beatrice
- Capodiferro, Arianna
- Russell, Ewan
- Palazzolo, Gemma
- Walton, Finlay
- Curia, Giulia
- Heidari, Hadi
Other Objects (12)
Bioresorbable Insertion Aids for Brain Implantable Flexible Probes: A Comparative Study on Silk Fibroin, Alginate, and Disaccharides
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Simultaneous structuring and mineralization of silk fibroin scaffolds
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Fiber Formation from Silk Fibroin Using Pressurized Gyration
Conductive regenerated silk fibroin composite fiber containing MWNTs
Photocrosslinked Silk Fibroin Microgel Scaffolds for Biomedical Applications
Stress Dissipation Encoded Silk Fibroin Electrode for the Athlete‐Beneficial Silk Bioelectronics
Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems
Biocompatible silk fibroin scaffold prepared by reactive inkjet printing
Bioresorbable Insertion Aids for Brain Implantable Flexible Probes: A Comparative Study on Silk Fibroin, Alginate, and Disaccharides
Production of silk sericin/silk fibroin blend nanofibers
Optimizing protein delivery rate from silk fibroin hydrogel using silk fibroin-mimetic peptides conjugation
A hybrid structure based on silk fibroin/PVA nanofibers and alginate/gum tragacanth hydrogel embedded with cardamom extract
Simultaneous structuring and mineralization of silk fibroin scaffolds
Conductive regenerated silk fibroin composite fiber containing MWNTs
Fiber Formation from Silk Fibroin Using Pressurized Gyration
Conductive regenerated silk fibroin composite fiber containing MWNTs
Photocrosslinked Silk Fibroin Microgel Scaffolds for Biomedical Applications
Stress Dissipation Encoded Silk Fibroin Electrode for the Athlete‐Beneficial Silk Bioelectronics
Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems
Biocompatible silk fibroin scaffold prepared by reactive inkjet printing
Bioresorbable Insertion Aids for Brain Implantable Flexible Probes: A Comparative Study on Silk Fibroin, Alginate, and Disaccharides
Production of silk sericin/silk fibroin blend nanofibers
Optimizing protein delivery rate from silk fibroin hydrogel using silk fibroin-mimetic peptides conjugation
A hybrid structure based on silk fibroin/PVA nanofibers and alginate/gum tragacanth hydrogel embedded with cardamom extract
Simultaneous structuring and mineralization of silk fibroin scaffolds
Conductive regenerated silk fibroin composite fiber containing MWNTs
Fiber Formation from Silk Fibroin Using Pressurized Gyration
Conductive regenerated silk fibroin composite fiber containing MWNTs
Photocrosslinked Silk Fibroin Microgel Scaffolds for Biomedical Applications
Stress Dissipation Encoded Silk Fibroin Electrode for the Athlete‐Beneficial Silk Bioelectronics
Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems