Patient‐Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy
Abstract: There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors and paired liver metastatic lesions is successfully constructed. CRLM PDOs from the multiomics levels (histopathology, genome, transcriptome and single‐cell sequencing) are comprehensively analyzed and confirmed that this organoid platform for CRLM could capture intra‐ and interpatient heterogeneity. The chemosensitivity data in vitro reveal the potential value of clinical application for PDOs to predict chemotherapy response (FOLFOX or FOLFIRI) and clinical prognosis of CRLM patients. Taken together, CRLM PDOs can be utilized to deliver a potential application for personalized medicine.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Patient‐Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy ; day:04 ; month:09 ; year:2022 ; extent:16
Advanced science ; (04.09.2022) (gesamt 16)
- Urheber
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Mo, Shaobo
Tang, Peiyuan
Luo, Wenqin
Zhang, Long
Li, Yaqi
Hu, Xiang
Ma, Xiaoji
Chen, Yikuan
Bao, Yichao
He, Xingfeng
Fu, Guoxiang
Xu, Xiaoya
Rao, Xinxin
Li, Xiaomeng
Guan, Ruoyu
Chen, Shengzhi
Deng, Yun
Lv, Tao
Mu, Peiyuan
Zheng, Qiang
Wang, Simin
Liu, Fangqi
Li, Yiwei
Sheng, Weiqi
Huang, Dan
Hu, Chen
Gao, Jianjun
Zhang, Zhen
Cai, Sanjun
Clevers, Hans
Peng, Junjie
Hua, Guoqiang
- DOI
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10.1002/advs.202204097
- URN
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urn:nbn:de:101:1-2022090515075493595742
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:37 MESZ
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Beteiligte
- Mo, Shaobo
- Tang, Peiyuan
- Luo, Wenqin
- Zhang, Long
- Li, Yaqi
- Hu, Xiang
- Ma, Xiaoji
- Chen, Yikuan
- Bao, Yichao
- He, Xingfeng
- Fu, Guoxiang
- Xu, Xiaoya
- Rao, Xinxin
- Li, Xiaomeng
- Guan, Ruoyu
- Chen, Shengzhi
- Deng, Yun
- Lv, Tao
- Mu, Peiyuan
- Zheng, Qiang
- Wang, Simin
- Liu, Fangqi
- Li, Yiwei
- Sheng, Weiqi
- Huang, Dan
- Hu, Chen
- Gao, Jianjun
- Zhang, Zhen
- Cai, Sanjun
- Clevers, Hans
- Peng, Junjie
- Hua, Guoqiang
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