Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies
Abstract: Directional cell migration is a critical process underlying morphogenesis and post‐natal tissue regeneration. During embryonic myogenesis, migration of skeletal myogenic progenitors is essential to generate the anlagen of limbs, diaphragm and tongue, whereas in post‐natal skeletal muscles, migration of muscle satellite (stem) cells towards regions of injury is necessary for repair and regeneration of muscle fibres. Additionally, safe and efficient migration of transplanted cells is critical in cell therapies, both allogeneic and autologous. Although various myogenic cell types have been administered intramuscularly or intravascularly, functional restoration has not been achieved yet in patients with degenerative diseases affecting multiple large muscles. One of the key reasons for this negative outcome is the limited migration of donor cells, which hinders the overall cell engraftment potential. Here, we review mechanisms of myogenic stem/progenitor cell migration during skeletal muscle development and post‐natal regeneration. Furthermore, strategies utilised to improve migratory capacity of myogenic cells are examined in order to identify potential treatments that may be applied to future transplantation protocols.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies ; volume:12 ; number:12 ; year:2020 ; extent:18
EMBO molecular medicine / European Molecular Biology Organization ; 12, Heft 12 (2020) (gesamt 18)
- Creator
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Choi, SungWoo
Ferrari, Giulia
Tedesco, Francesco Saverio
- DOI
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10.15252/emmm.202012357
- URN
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urn:nbn:de:101:1-2022070509282966532243
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:21 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Choi, SungWoo
- Ferrari, Giulia
- Tedesco, Francesco Saverio
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