Electrospun coaxial hyaluronan-based fiber networks for ophthalmic drug release
Abstract: A micro-sized core-shell drug release device has been prepared by coaxial electrospinning based on a polylactide shell and the inner core phase made of high molecular weight hyaluronan or a cross-linked hyaluronan network. Timolol, which was inserted into the core phase, is widely used as drug for glaucoma treatment to depress the intraocular eye pressure and should be released over a longer time period from this fiber networks. Release studies of drug loaded fiber devices showed an only moderate burst release of timolol in the first days followed by a continuous longlasting drug release period over several weeks. With these findings, coaxial electrospinning represents a promising approach for the development of drug release systems with long-lasting, relatively constant drug delivery.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Electrospun coaxial hyaluronan-based fiber networks for ophthalmic drug release ; volume:7 ; number:2 ; year:2021 ; pages:688-691 ; extent:4
Current directions in biomedical engineering ; 7, Heft 2 (2021), 688-691 (gesamt 4)
- Creator
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Walter, Torsten
Wyrwa, Ralf
Altmann, Cindy
Schnabelrauch, Matthias
- DOI
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10.1515/cdbme-2021-2175
- URN
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urn:nbn:de:101:1-2022101214124485171599
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
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Associated
- Walter, Torsten
- Wyrwa, Ralf
- Altmann, Cindy
- Schnabelrauch, Matthias
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